Platelet adhesion receptors

Michael J. Williams, Xiaoping Du, Joseph C. Loftus, Mark H. Ginsberg

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The response to vascular injury involves attachment and aggregation of platelets, coupled with initiation of the coagulation cascade. These inter-related processes ensure that the vessel injury is rapidly blocked with an aggregated clump of platelets that is then stabilized by a crosslinked fibrin matrix. Initial adherence relies on the ability of the platelet adhesion receptors to bind subendothelial matrix molecules. Platelet activation then results in the expression of high affinity integrin receptors on the cell surface that bind soluble ligands, allowing platelets to aggregate and form a haemostatic plug.

Original languageEnglish (US)
Pages (from-to)305-314
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume6
Issue number5
StatePublished - Jan 1 1995

Keywords

  • GPib-IX
  • Integrins
  • Platelets
  • Receptors
  • αIIbβ3

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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    Williams, M. J., Du, X., Loftus, J. C., & Ginsberg, M. H. (1995). Platelet adhesion receptors. Seminars in Cell and Developmental Biology, 6(5), 305-314.