Platelet activation and its patient-specific consequences

Susan S. Smyth, Dougald M. Monroe, Waldemar E. Wysokinski, Robert D. McBane, Sidney W. Whiteheart, Richard C. Becker, Steven R. Steinhubl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Individuals vary in their thrombotic response to vascular injury. The reasons for this are numerous, involving heterogeneity in multiple platelet responses. Platelet research has tended to focus on functioning at the molecular level, and many experiments reflect results obtained in isolated, in vitro systems. However, platelets function in a complex and dynamic in vivo environment with the potential for a wide range of biological influences. This article reviews the evidence for diversity in platelet responses and the implications for individual variability in propensity to arterial thrombosis. Three overarching phenomena are considered. First, platelets can vary quantitatively and qualitatively in their responses to agonists. Second, platelets appear to have different intrinsic levels of procoagulant activity. Third, responses to various procoagulant, regulatory, and mediating factors likewise differ within and among individuals and can be influenced by blood-borne factors. These phenomena may help to explain differences in experimental arterial thrombosis observed in individuals.

Original languageEnglish (US)
Pages (from-to)435-441
Number of pages7
JournalThrombosis Research
Volume122
Issue number4
DOIs
StatePublished - 2008

Fingerprint

Platelet Activation
Blood Platelets
Thrombosis
Vascular System Injuries
Research

Keywords

  • Activation
  • Hemostasis
  • Platelets
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Smyth, S. S., Monroe, D. M., Wysokinski, W. E., McBane, R. D., Whiteheart, S. W., Becker, R. C., & Steinhubl, S. R. (2008). Platelet activation and its patient-specific consequences. Thrombosis Research, 122(4), 435-441. https://doi.org/10.1016/j.thromres.2007.08.023

Platelet activation and its patient-specific consequences. / Smyth, Susan S.; Monroe, Dougald M.; Wysokinski, Waldemar E.; McBane, Robert D.; Whiteheart, Sidney W.; Becker, Richard C.; Steinhubl, Steven R.

In: Thrombosis Research, Vol. 122, No. 4, 2008, p. 435-441.

Research output: Contribution to journalArticle

Smyth, SS, Monroe, DM, Wysokinski, WE, McBane, RD, Whiteheart, SW, Becker, RC & Steinhubl, SR 2008, 'Platelet activation and its patient-specific consequences', Thrombosis Research, vol. 122, no. 4, pp. 435-441. https://doi.org/10.1016/j.thromres.2007.08.023
Smyth SS, Monroe DM, Wysokinski WE, McBane RD, Whiteheart SW, Becker RC et al. Platelet activation and its patient-specific consequences. Thrombosis Research. 2008;122(4):435-441. https://doi.org/10.1016/j.thromres.2007.08.023
Smyth, Susan S. ; Monroe, Dougald M. ; Wysokinski, Waldemar E. ; McBane, Robert D. ; Whiteheart, Sidney W. ; Becker, Richard C. ; Steinhubl, Steven R. / Platelet activation and its patient-specific consequences. In: Thrombosis Research. 2008 ; Vol. 122, No. 4. pp. 435-441.
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