TY - JOUR
T1 - Plasticity of melanotrope cell regulations in Xenopus laevis
AU - Roubos, Eric W.
AU - Van Wijk, Diane C.W.A.
AU - Kozicz, Tamás
AU - Scheenen, Wim J.J.M.
AU - Jenks, Bruce G.
PY - 2010/12
Y1 - 2010/12
N2 - This review focuses on the plasticity of the regulation of a particular neuroendocrine transducer cell, the melanotrope cell in the pituitary pars intermedia of the amphibian Xenopus laevis. This cell type is a suitable model to study the relationship between various external regulatory inputs and the secretion of an adaptive endocrine message, in this case the release of α-melanophore-stimulating hormone, which activates skin melanophores to darken when the animal is placed on a dark background. Information about the environmental conditions is processed by various brain centres, in the hypothalamus and elsewhere, that eventually control the activity of the melanotrope cell regarding hormone production and secretion. The review discusses the roles of these hypothalamic and extrahypothalamic nuclei, their neurochemical messengers acting on the melanotrope, and the external stimuli they mediate to control melanotrope cell functioning.
AB - This review focuses on the plasticity of the regulation of a particular neuroendocrine transducer cell, the melanotrope cell in the pituitary pars intermedia of the amphibian Xenopus laevis. This cell type is a suitable model to study the relationship between various external regulatory inputs and the secretion of an adaptive endocrine message, in this case the release of α-melanophore-stimulating hormone, which activates skin melanophores to darken when the animal is placed on a dark background. Information about the environmental conditions is processed by various brain centres, in the hypothalamus and elsewhere, that eventually control the activity of the melanotrope cell regarding hormone production and secretion. The review discusses the roles of these hypothalamic and extrahypothalamic nuclei, their neurochemical messengers acting on the melanotrope, and the external stimuli they mediate to control melanotrope cell functioning.
KW - Magnocellular nucleus
KW - Neuropeptides
KW - POMC
KW - Plasticity
KW - Suprachiasmatic nucleus
KW - α-MSH
UR - http://www.scopus.com/inward/record.url?scp=78650035584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650035584&partnerID=8YFLogxK
U2 - 10.1111/j.1460-9568.2010.07526.x
DO - 10.1111/j.1460-9568.2010.07526.x
M3 - Article
C2 - 21143662
AN - SCOPUS:78650035584
SN - 0953-816X
VL - 32
SP - 2082
EP - 2086
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
IS - 12
ER -