TY - JOUR
T1 - Plasticity of human menstrual blood stem cells derived from the endometrium
AU - Lin, Jian
AU - Xiang, Dennis
AU - Zhang, Jin Long
AU - Allickson, Julie
AU - Xiang, Charlie
N1 - Funding Information:
‡ Corresponding author * Project supported by the National Science and Technology Major Project of China (No. 2008ZX10002-009), and the National Basic Research Program (973) of China (No. 2007CB513001) © Zhejiang University and Springer-Verlag Berlin Heidelberg 2011
PY - 2011/5
Y1 - 2011/5
N2 - Stem cells can be obtained from women's menstrual blood derived from the endometrium. The cells display stem cell markers such as Oct-4, SSEA-4, Nanog, and c-kit (CD117), and have the potent ability to differentiate into various cell types, including the heart, nerve, bone, cartilage, and fat. There has been no evidence of teratoma, ectopic formation, or any immune response after transplantation into an animal model. These cells quickly regenerate after menstruation and secrete many growth factors to display recurrent angiogenesis. The plasticity and safety of the acquired cells have been demonstrated in many studies. Menstrual blood-derived stem cells (MenSCs) provide an alternative source of adult stem cells for research and application in regenerative medicine. Here we summarize the multipotent properties and the plasticities of MenSCs and other endometrial stem cells from recent studies conducted both in vitro and in vivo.
AB - Stem cells can be obtained from women's menstrual blood derived from the endometrium. The cells display stem cell markers such as Oct-4, SSEA-4, Nanog, and c-kit (CD117), and have the potent ability to differentiate into various cell types, including the heart, nerve, bone, cartilage, and fat. There has been no evidence of teratoma, ectopic formation, or any immune response after transplantation into an animal model. These cells quickly regenerate after menstruation and secrete many growth factors to display recurrent angiogenesis. The plasticity and safety of the acquired cells have been demonstrated in many studies. Menstrual blood-derived stem cells (MenSCs) provide an alternative source of adult stem cells for research and application in regenerative medicine. Here we summarize the multipotent properties and the plasticities of MenSCs and other endometrial stem cells from recent studies conducted both in vitro and in vivo.
KW - Endometrium
KW - Menstrual blood-derived stem cells (MenSCs)
KW - Multipotent
KW - Plasticity
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U2 - 10.1631/jzus.B1100015
DO - 10.1631/jzus.B1100015
M3 - Review article
C2 - 21528491
AN - SCOPUS:79956227324
SN - 1673-1581
VL - 12
SP - 372
EP - 380
JO - Journal of Zhejiang University: Science B
JF - Journal of Zhejiang University: Science B
IS - 5
ER -