Abstract
We present six patients with acute fulminant episodes of CNS inflammatory demyelination who responded to therapeutic plasmapheresis after failing a course of high-dose methylprednisolone administered IV. Neurologic improvement occurred in three of the patients following the second plasmapheresis. Dramatic improvement in motor function (four patients) and language (two patients) began within 2 to 14 days and persisted during the 6 to 35 months (mean, 15 months) of follow-up. Results of this uncontrolled study suggest that plasmapheresis in the absence of other immunosuppressive drugs may have a role in the treatment of severe episodes of inflammatory demyelination in a select subset of MS patients.
Original language | English (US) |
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Pages (from-to) | 1100-1104 |
Number of pages | 5 |
Journal | Neurology |
Volume | 43 |
Issue number | 6 |
State | Published - Jun 1993 |
ASJC Scopus subject areas
- Clinical Neurology