Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination

Moses Rodriguez, William E. Karnes, J. D. Bartleson, Alvaro A. Pineda

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

We present six patients with acute fulminant episodes of CNS inflammatory demyelination who responded to therapeutic plasmapheresis after failing a course of high-dose methylprednisolone administered IV. Neurologic improvement occurred in three of the patients following the second plasmapheresis. Dramatic improvement in motor function (four patients) and language (two patients) began within 2 to 14 days and persisted during the 6 to 35 months (mean, 15 months) of follow-up. Results of this uncontrolled study suggest that plasmapheresis in the absence of other immunosuppressive drugs may have a role in the treatment of severe episodes of inflammatory demyelination in a select subset of MS patients.

Original languageEnglish (US)
Pages (from-to)1100-1104
Number of pages5
JournalNeurology
Volume43
Issue number6
StatePublished - Jun 1993

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Plasmapheresis
Demyelinating Diseases
Methylprednisolone
Immunosuppressive Agents
Nervous System
Language
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rodriguez, M., Karnes, W. E., Bartleson, J. D., & Pineda, A. A. (1993). Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination. Neurology, 43(6), 1100-1104.

Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination. / Rodriguez, Moses; Karnes, William E.; Bartleson, J. D.; Pineda, Alvaro A.

In: Neurology, Vol. 43, No. 6, 06.1993, p. 1100-1104.

Research output: Contribution to journalArticle

Rodriguez, M, Karnes, WE, Bartleson, JD & Pineda, AA 1993, 'Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination', Neurology, vol. 43, no. 6, pp. 1100-1104.
Rodriguez M, Karnes WE, Bartleson JD, Pineda AA. Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination. Neurology. 1993 Jun;43(6):1100-1104.
Rodriguez, Moses ; Karnes, William E. ; Bartleson, J. D. ; Pineda, Alvaro A. / Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination. In: Neurology. 1993 ; Vol. 43, No. 6. pp. 1100-1104.
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