Plasma proteome database

Malabika Sarker, G. Hanumanthu, Akhilesh Pandey

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The plasma proteome is one of the most important proteomes from a diagnostic standpoint, as quantitative changes between normal and diseased states can be used to discover novel biomarkers for clinical diagnosis and therapeutic monitoring of diseases. HUPO's Plasma Proteome Project has involved characterization of the plasma proteome by an international consortium using technologies ranging from antibody arrays to mass spectrometry and has helped in the construction of a substantial catalog of plasma proteins. Our group has developed the Plasma Proteome Database (http://www.plasmaproteomedatabase.org) as a comprehensive resource of annotated data for posttranslational modifications, single-nucleotide polymorphisms, tissue expression, subcellular localization, and disease involvement of plasma proteins. This database should serve to facilitate further research to help understand the plasma proteome in health and disease.

Original languageEnglish (US)
Title of host publicationProteomics of Human Body Fluids
Subtitle of host publicationPrinciples, Methods, and Applications
PublisherHumana Press Inc.
Pages129-136
Number of pages8
ISBN (Electronic)9781597454322
ISBN (Print)9781588296573
DOIs
StatePublished - Jan 1 2007

Keywords

  • Proteomics
  • annotation
  • bioinformatics
  • database
  • mass spectrometry
  • plasma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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