TY - JOUR
T1 - Plasma protein binding of phenytoin in the aged
T2 - in vivo studies.
AU - Patterson, M.
AU - Heazelwood, R.
AU - Smithurst, B.
AU - Eadie, MJ
PY - 1982/3
Y1 - 1982/3
N2 - 1 The relation between plasma water phenytoin content and whole plasma phenytoin content in vivo was studied in 22 elderly patients (age range 62 to 87 years) and in 22 young patients (age range 18 to 33 years), all of whom were taking the drug for epilepsy. 2 The percentage of the drug existing unbound in plasma was slightly, but statistically significantly, higher in the elderly (12.8 +/‐ 1.8%) than in the young (11.1 +/‐ 2.5%). Reduced plasma albumin levels in the elderly (33.0 +/‐ 2.0 gl‐1) as compared with the young (45.3 +/‐ 3.5 gl‐1) probably contributed to the reduced protein binding in the older subjects. 1982 The British Pharmacological Society
AB - 1 The relation between plasma water phenytoin content and whole plasma phenytoin content in vivo was studied in 22 elderly patients (age range 62 to 87 years) and in 22 young patients (age range 18 to 33 years), all of whom were taking the drug for epilepsy. 2 The percentage of the drug existing unbound in plasma was slightly, but statistically significantly, higher in the elderly (12.8 +/‐ 1.8%) than in the young (11.1 +/‐ 2.5%). Reduced plasma albumin levels in the elderly (33.0 +/‐ 2.0 gl‐1) as compared with the young (45.3 +/‐ 3.5 gl‐1) probably contributed to the reduced protein binding in the older subjects. 1982 The British Pharmacological Society
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U2 - 10.1111/j.1365-2125.1982.tb01396.x
DO - 10.1111/j.1365-2125.1982.tb01396.x
M3 - Article
C2 - 7059445
AN - SCOPUS:0020432969
SN - 0306-5251
VL - 13
SP - 423
EP - 425
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 3
ER -