Plasma protein binding of phenytoin in the aged: In vivo studies

M. Patterson, R. Heazelwood, B. Smithurst, M. J. Eadie

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The relation between plasma water phenytoin content and whole plasma phenytoin content in vivo was studied in 22 elderly patients (age range 62 to 87 years) and in 22 young patients (age range 18 to 33 years), all of whom were taking the drug for epilepsy. The percentage of the drug existing unbound in plasma was slightly, but statistically significantly, higher in the elderly (12.8 ± 1.8%) than in the young (11.1 ± 2.5%). Reduced plasma albumin levels in the elderly (33.0 ± 2.0 g l-1) as compared with the young (45.3 ± 3.5 g l-1) probably contributed to the reduced protein binding in the older subjects.

Original languageEnglish (US)
Pages (from-to)423-425
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume13
Issue number3
StatePublished - 1982
Externally publishedYes

Fingerprint

Phenytoin
Protein Binding
Blood Proteins
Serum Albumin
Pharmaceutical Preparations
Epilepsy
Water

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Patterson, M., Heazelwood, R., Smithurst, B., & Eadie, M. J. (1982). Plasma protein binding of phenytoin in the aged: In vivo studies. British Journal of Clinical Pharmacology, 13(3), 423-425.

Plasma protein binding of phenytoin in the aged : In vivo studies. / Patterson, M.; Heazelwood, R.; Smithurst, B.; Eadie, M. J.

In: British Journal of Clinical Pharmacology, Vol. 13, No. 3, 1982, p. 423-425.

Research output: Contribution to journalArticle

Patterson, M, Heazelwood, R, Smithurst, B & Eadie, MJ 1982, 'Plasma protein binding of phenytoin in the aged: In vivo studies', British Journal of Clinical Pharmacology, vol. 13, no. 3, pp. 423-425.
Patterson M, Heazelwood R, Smithurst B, Eadie MJ. Plasma protein binding of phenytoin in the aged: In vivo studies. British Journal of Clinical Pharmacology. 1982;13(3):423-425.
Patterson, M. ; Heazelwood, R. ; Smithurst, B. ; Eadie, M. J. / Plasma protein binding of phenytoin in the aged : In vivo studies. In: British Journal of Clinical Pharmacology. 1982 ; Vol. 13, No. 3. pp. 423-425.
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