Abstract
Introduction: Phospholipids are altered in brains of patients with dementia and some studies suggest their plasma levels may be useful in the detection of mild cognitive impairment (MCI) and dementia. Methods: We measured 188 plasma metabolites in participants who underwent a detailed neuropsychological assessment and classified as normal (n = 153), MCI (n = 145), or dementia (n = 143) by expert adjudication. Results: Among 10 phospholipids recently implicated as altered in dementia, higher concentration of PC aa C36:6 was significantly associated with decreased prevalence of dementia (odds ratio = 0.71, 95% confidence interval = 0.50-1.00 per 1-SD increase). Adding these phospholipids to a model including multiple predictors of dementia led to only minimal improvement in detection (C statistic changed from 0.702 to 0.71). Discussion: Some phospholipids and metabolites were altered in MCI and dementia but cross-sectional association was relatively weak and did not improve detection of MCI and dementia beyond information provided by clinical variables.
Original language | English (US) |
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Pages (from-to) | 73-82 |
Number of pages | 10 |
Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Volume | 3 |
DOIs | |
State | Published - 2016 |
Keywords
- AD
- ARIC
- ARIC-NCS
- Alzheimer's disease
- Dementia
- MCI
- Metabolites
- Metabolomics
- Mild cognitive impairment
- Phospholipids
- Plasma
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health