Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography

Michelle M. Mielke, Clinton E. Hagen, Jing Xu, Xiyun Chai, Prashanthi Vemuri, Val J. Lowe, David C. Airey, David S. Knopman, Rosebud O. Roberts, Mary M. Machulda, Clifford R. Jack, Ronald C. Petersen, Jeffrey L. Dage

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Introduction: We examined and compared plasma phospho-tau181 (pTau181) and total tau: (1) across the Alzheimer's disease (AD) clinical spectrum; (2) in relation to brain amyloid β (Aβ) positron emission tomography (PET), tau PET, and cortical thickness; and (3) as a screening tool for elevated brain Aβ. Methods: Participants included 172 cognitively unimpaired, 57 mild cognitively impaired, and 40 AD dementia patients with concurrent Aβ PET (Pittsburgh compound B), tau PET (AV1451), magnetic resonance imaging, plasma total tau, and pTau181. Results: Plasma total tau and pTau181 levels were higher in AD dementia patients than those in cognitively unimpaired. Plasma pTau181 was more strongly associated with both Aβ and tau PET. Plasma pTau181 was a more sensitive and specific predictor of elevated brain Aβ than total tau and was as good as, or better than, the combination of age and apolipoprotein E (APOE). Discussion: Plasma pTau181 may have utility as a biomarker of AD pathophysiology and as a noninvasive screener for elevated brain Aβ.

Original languageEnglish (US)
Pages (from-to)989-997
Number of pages9
JournalAlzheimer's and Dementia
Volume14
Issue number8
DOIs
StatePublished - Aug 2018

Keywords

  • Alzheimer's disease
  • Amyloid PET
  • Plasma phosphorylated tau
  • Plasma tau
  • Predicting brain amyloid
  • Tau PET

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography'. Together they form a unique fingerprint.

  • Cite this