Plasma mitochondrial DNA levels were independently associated with lung injury in elderly hip fracture patients

Jian zheng Zhang, Juan Wang, Wenchun Qu, Xiao wei Wang, Zhi Liu, Ji xin Ren, Li Han, Tian sheng Sun

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction Hip fracture in the elderly can induce systemic inflammatory response (SIRS) and lung injury which increases the risk of lung infection and death. Mitochondrial DNA (mtDNA) plays a role in SIRS and lung injury in patients with multi-trauma, and also in patients with hip fractures. This study evaluated the potential value of plasma mtDNA in the early prognosis of lung injury in elderly fracture patients. Methods This study enrolled 156 elderly patients with intertrochanteric fracture. Plasma mtDNA, IL-6, IL-10, prostaglandin E2 (PGE2) levels were measured at admission. Sixty-one and 31 patients were diagnosed with systemic inflammatory response syndrome (SIRS) and lung injury, respectively. Results Plasma mtDNA levels were higher in hip fracture patients compared to healthy controls (P < 0.001) and significantly higher in the lung injury subgroup compared to the lung injury absent subgroup (P < 0.001). MtDNA levels were correlated with the SIRS score (r = 0.446, P < 0.001), IL-6 (r = 0.506, P < 0.001), IL-10 (r = 0.523, P < 0.001), and PGE2 (r = 0.360, P < 0.001). Logistic regression analysis revealed that plasma mtDNA, IL-6, PGE2 and SIRS score were independent predictors of the risk of lung injury. Conclusion Plasma mtDNA release induced by hip fracture in elderly patients, might be an early predictor of lung injury in these patients.

Original languageEnglish (US)
Pages (from-to)454-459
Number of pages6
JournalInjury
Volume48
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Hip Fractures
Lung Injury
Mitochondrial DNA
Dinoprostone
Interleukin-6
Interleukin-10
Systemic Inflammatory Response Syndrome
Logistic Models
Regression Analysis
Lung
Wounds and Injuries
Infection

Keywords

  • Hip fracture
  • Lung injury
  • Mitochondrial DNA
  • Predictor
  • Surgery
  • Systemic inflammatory response syndrome

ASJC Scopus subject areas

  • Emergency Medicine
  • Orthopedics and Sports Medicine

Cite this

Plasma mitochondrial DNA levels were independently associated with lung injury in elderly hip fracture patients. / Zhang, Jian zheng; Wang, Juan; Qu, Wenchun; Wang, Xiao wei; Liu, Zhi; Ren, Ji xin; Han, Li; Sun, Tian sheng.

In: Injury, Vol. 48, No. 2, 01.02.2017, p. 454-459.

Research output: Contribution to journalArticle

Zhang, Jian zheng ; Wang, Juan ; Qu, Wenchun ; Wang, Xiao wei ; Liu, Zhi ; Ren, Ji xin ; Han, Li ; Sun, Tian sheng. / Plasma mitochondrial DNA levels were independently associated with lung injury in elderly hip fracture patients. In: Injury. 2017 ; Vol. 48, No. 2. pp. 454-459.
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abstract = "Introduction Hip fracture in the elderly can induce systemic inflammatory response (SIRS) and lung injury which increases the risk of lung infection and death. Mitochondrial DNA (mtDNA) plays a role in SIRS and lung injury in patients with multi-trauma, and also in patients with hip fractures. This study evaluated the potential value of plasma mtDNA in the early prognosis of lung injury in elderly fracture patients. Methods This study enrolled 156 elderly patients with intertrochanteric fracture. Plasma mtDNA, IL-6, IL-10, prostaglandin E2 (PGE2) levels were measured at admission. Sixty-one and 31 patients were diagnosed with systemic inflammatory response syndrome (SIRS) and lung injury, respectively. Results Plasma mtDNA levels were higher in hip fracture patients compared to healthy controls (P < 0.001) and significantly higher in the lung injury subgroup compared to the lung injury absent subgroup (P < 0.001). MtDNA levels were correlated with the SIRS score (r = 0.446, P < 0.001), IL-6 (r = 0.506, P < 0.001), IL-10 (r = 0.523, P < 0.001), and PGE2 (r = 0.360, P < 0.001). Logistic regression analysis revealed that plasma mtDNA, IL-6, PGE2 and SIRS score were independent predictors of the risk of lung injury. Conclusion Plasma mtDNA release induced by hip fracture in elderly patients, might be an early predictor of lung injury in these patients.",
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N2 - Introduction Hip fracture in the elderly can induce systemic inflammatory response (SIRS) and lung injury which increases the risk of lung infection and death. Mitochondrial DNA (mtDNA) plays a role in SIRS and lung injury in patients with multi-trauma, and also in patients with hip fractures. This study evaluated the potential value of plasma mtDNA in the early prognosis of lung injury in elderly fracture patients. Methods This study enrolled 156 elderly patients with intertrochanteric fracture. Plasma mtDNA, IL-6, IL-10, prostaglandin E2 (PGE2) levels were measured at admission. Sixty-one and 31 patients were diagnosed with systemic inflammatory response syndrome (SIRS) and lung injury, respectively. Results Plasma mtDNA levels were higher in hip fracture patients compared to healthy controls (P < 0.001) and significantly higher in the lung injury subgroup compared to the lung injury absent subgroup (P < 0.001). MtDNA levels were correlated with the SIRS score (r = 0.446, P < 0.001), IL-6 (r = 0.506, P < 0.001), IL-10 (r = 0.523, P < 0.001), and PGE2 (r = 0.360, P < 0.001). Logistic regression analysis revealed that plasma mtDNA, IL-6, PGE2 and SIRS score were independent predictors of the risk of lung injury. Conclusion Plasma mtDNA release induced by hip fracture in elderly patients, might be an early predictor of lung injury in these patients.

AB - Introduction Hip fracture in the elderly can induce systemic inflammatory response (SIRS) and lung injury which increases the risk of lung infection and death. Mitochondrial DNA (mtDNA) plays a role in SIRS and lung injury in patients with multi-trauma, and also in patients with hip fractures. This study evaluated the potential value of plasma mtDNA in the early prognosis of lung injury in elderly fracture patients. Methods This study enrolled 156 elderly patients with intertrochanteric fracture. Plasma mtDNA, IL-6, IL-10, prostaglandin E2 (PGE2) levels were measured at admission. Sixty-one and 31 patients were diagnosed with systemic inflammatory response syndrome (SIRS) and lung injury, respectively. Results Plasma mtDNA levels were higher in hip fracture patients compared to healthy controls (P < 0.001) and significantly higher in the lung injury subgroup compared to the lung injury absent subgroup (P < 0.001). MtDNA levels were correlated with the SIRS score (r = 0.446, P < 0.001), IL-6 (r = 0.506, P < 0.001), IL-10 (r = 0.523, P < 0.001), and PGE2 (r = 0.360, P < 0.001). Logistic regression analysis revealed that plasma mtDNA, IL-6, PGE2 and SIRS score were independent predictors of the risk of lung injury. Conclusion Plasma mtDNA release induced by hip fracture in elderly patients, might be an early predictor of lung injury in these patients.

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