Plasma membrane calcium ATPase activity is regulated by actin oligomers through direct interaction

Marianela G. Dalghi, Marisa M. Fernández, Mariela Ferreira-Gomes, Irene C. Mangialavori, Emilio L. Malchiodi, Emanuel E. Strehler, Juan Pablo F.C. Rossi

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Plasma membrane calcium ATPases interact dynamically with the submembrane actin cytoskeleton. Results: Biophysical and functional assays show that purified plasma membrane calcium ATPase binds to G-actin and is activated by short actin oligomers. Conclusion: Plasma membrane calcium ATPases are regulated by polymerizing actin independently of regulation by calmodulin. Significance: Dynamic actin participates in cytosolic Ca2+ homeostasis by regulating plasma membrane calcium ATPase activity.

Original languageEnglish (US)
Pages (from-to)23380-23393
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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