Plasma levels of tumour necrosis factor alpha and interleukin-6 predict progression-free survival following thalidomide therapy in patients with previously untreated multiple myeloma

Michael A. Thompson, Thomas E. Witzig, Shaji Kumar, Michael M. Timm, Jessica Haug, Rafael Fonseca, Philip R. Greipp, John A. Lust, S. Vincent Rajkumar

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We studied marrow angiogenesis and plasma levels of angiogenic cytokines in 38 patients receiving thalidomide therapy for previously untreated myeloma. The effect of therapy and the relationship of cytokine levels to myeloma cell proliferation, bone marrow microvessel density and progression-free survival (PFS) were studied. High pretreatment tumour necrosis factor-α (TNFα) levels (> 11 pg/ml) and increased interleukin (IL)-6 of > 2 pg/ml predicted for poorer PFS (TNFα, 48% versus 74% at 2 years, P = 0. 01; IL-6, 24% versus 70% at 2 years, P = 0.01). None of the other parameters predicted response or PFS, and no significant changes in cytokine levels occurred with therapy.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalBritish journal of haematology
Volume123
Issue number2
DOIs
StatePublished - Oct 2003

Keywords

  • Angiogenesis
  • Cytokines
  • Multiple myeloma
  • Prognosis
  • Therapy

ASJC Scopus subject areas

  • Hematology

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