Plasma exchange for severe attacks of CNS demyelination: Predictors of response

B Mark Keegan, A. A. Pineda, R. L. McClelland, C. H. Darby, M. Rodriguez, Brian G Weinshenker

Research output: Contribution to journalArticle

440 Citations (Scopus)

Abstract

The authors reviewed 59 consecutive patients treated with plasma exchange (PE) for acute, severe attacks of CNS demyelination at Mayo Clinic from January 1984 through June 2000. Most patients had relapsing-remitting MS (n = 22, 37.3%), neuromyelitis optica (NMO) (n = 10, 16.9%), and acute disseminated encephalomyelitis (n = 10, 16.9%). PE was followed by moderate or marked functional improvement in 44.1% of treated patients. Male sex (p = 0.021), preserved reflexes (p = 0.019), and early initiation of treatment (p = 0.009) were associated with moderate or marked improvement. Successfully treated patients improved rapidly following PE, and improvement was sustained.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalNeurology
Volume58
Issue number1
StatePublished - Jan 8 2002

Fingerprint

Plasma Exchange
Demyelinating Diseases
Acute Disseminated Encephalomyelitis
Neuromyelitis Optica
Reflex
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Keegan, B. M., Pineda, A. A., McClelland, R. L., Darby, C. H., Rodriguez, M., & Weinshenker, B. G. (2002). Plasma exchange for severe attacks of CNS demyelination: Predictors of response. Neurology, 58(1), 143-148.

Plasma exchange for severe attacks of CNS demyelination : Predictors of response. / Keegan, B Mark; Pineda, A. A.; McClelland, R. L.; Darby, C. H.; Rodriguez, M.; Weinshenker, Brian G.

In: Neurology, Vol. 58, No. 1, 08.01.2002, p. 143-148.

Research output: Contribution to journalArticle

Keegan, BM, Pineda, AA, McClelland, RL, Darby, CH, Rodriguez, M & Weinshenker, BG 2002, 'Plasma exchange for severe attacks of CNS demyelination: Predictors of response', Neurology, vol. 58, no. 1, pp. 143-148.
Keegan BM, Pineda AA, McClelland RL, Darby CH, Rodriguez M, Weinshenker BG. Plasma exchange for severe attacks of CNS demyelination: Predictors of response. Neurology. 2002 Jan 8;58(1):143-148.
Keegan, B Mark ; Pineda, A. A. ; McClelland, R. L. ; Darby, C. H. ; Rodriguez, M. ; Weinshenker, Brian G. / Plasma exchange for severe attacks of CNS demyelination : Predictors of response. In: Neurology. 2002 ; Vol. 58, No. 1. pp. 143-148.
@article{c13173f6086849028a4cc153878b95bf,
title = "Plasma exchange for severe attacks of CNS demyelination: Predictors of response",
abstract = "The authors reviewed 59 consecutive patients treated with plasma exchange (PE) for acute, severe attacks of CNS demyelination at Mayo Clinic from January 1984 through June 2000. Most patients had relapsing-remitting MS (n = 22, 37.3{\%}), neuromyelitis optica (NMO) (n = 10, 16.9{\%}), and acute disseminated encephalomyelitis (n = 10, 16.9{\%}). PE was followed by moderate or marked functional improvement in 44.1{\%} of treated patients. Male sex (p = 0.021), preserved reflexes (p = 0.019), and early initiation of treatment (p = 0.009) were associated with moderate or marked improvement. Successfully treated patients improved rapidly following PE, and improvement was sustained.",
author = "Keegan, {B Mark} and Pineda, {A. A.} and McClelland, {R. L.} and Darby, {C. H.} and M. Rodriguez and Weinshenker, {Brian G}",
year = "2002",
month = "1",
day = "8",
language = "English (US)",
volume = "58",
pages = "143--148",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Plasma exchange for severe attacks of CNS demyelination

T2 - Predictors of response

AU - Keegan, B Mark

AU - Pineda, A. A.

AU - McClelland, R. L.

AU - Darby, C. H.

AU - Rodriguez, M.

AU - Weinshenker, Brian G

PY - 2002/1/8

Y1 - 2002/1/8

N2 - The authors reviewed 59 consecutive patients treated with plasma exchange (PE) for acute, severe attacks of CNS demyelination at Mayo Clinic from January 1984 through June 2000. Most patients had relapsing-remitting MS (n = 22, 37.3%), neuromyelitis optica (NMO) (n = 10, 16.9%), and acute disseminated encephalomyelitis (n = 10, 16.9%). PE was followed by moderate or marked functional improvement in 44.1% of treated patients. Male sex (p = 0.021), preserved reflexes (p = 0.019), and early initiation of treatment (p = 0.009) were associated with moderate or marked improvement. Successfully treated patients improved rapidly following PE, and improvement was sustained.

AB - The authors reviewed 59 consecutive patients treated with plasma exchange (PE) for acute, severe attacks of CNS demyelination at Mayo Clinic from January 1984 through June 2000. Most patients had relapsing-remitting MS (n = 22, 37.3%), neuromyelitis optica (NMO) (n = 10, 16.9%), and acute disseminated encephalomyelitis (n = 10, 16.9%). PE was followed by moderate or marked functional improvement in 44.1% of treated patients. Male sex (p = 0.021), preserved reflexes (p = 0.019), and early initiation of treatment (p = 0.009) were associated with moderate or marked improvement. Successfully treated patients improved rapidly following PE, and improvement was sustained.

UR - http://www.scopus.com/inward/record.url?scp=0037039226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037039226&partnerID=8YFLogxK

M3 - Article

C2 - 11781423

AN - SCOPUS:0037039226

VL - 58

SP - 143

EP - 148

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 1

ER -