Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation

Amir Lerman, Spencer H. Kubo, Linda K. Tschumperlin, John C Jr. Burnett

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Objectives and Background. Endothelin is an endothelium-derived vasoconstrictor peptide that increases systemic and renal vascular resistance at pathophysiologic concentrations. Recent studies have demonstrated its presence in the circulation and its elevation in animals with congestive heart failure, suggesting that endothelin may contribute to the vasoconstrictive state of heart failure. The current study was designed with two objectives: 1) to demonstrate the elevation or circulating endothelin in patients with heart failure, and 2) to determine the short- and long-term response of endothelin levels after heart transplantation. Methods. Plasma endothelin concentrations were measured in two patient groups. Group 1 included 24 patients with end-stage heart failure who were studied during evaluation for potential heart transplantation. Group 2 included 12 patients from Group 1 who had had heart transplantation. Plasma endothelin concentrations were measured before and on days 1, 3 and 7 after heart transplantation. Eight of these patients also had levels measured 3 to 12 months later. Results. Plasma endothelin concentrations were significantly elevated in patients with heart failure compared with those in an age-matched control group (11.7 ± 1.1 vs. 6.8 ± 0.3 pg/ml). In response to heart transplantation, plasma eadothelin concentrations increased further and were sustained during a long-term follow-up. These later changes were associated with a significant increase in arterial pressure and serum creatinine. Conclusions. This study demonstrates that endothelin concentrations are increased in patients with heart failure and increase further after heart transplantation. It suggests a possible role for endothelin in the cardiovascular and renal adaptive responses to human heart transplantation.

Original languageEnglish (US)
Pages (from-to)849-853
Number of pages5
JournalJournal of the American College of Cardiology
Volume20
Issue number4
DOIs
StatePublished - 1992

Fingerprint

Endothelins
Heart Transplantation
Heart Failure
Kidney
Vasoconstrictor Agents
Vascular Resistance
Endothelium
Creatinine
Arterial Pressure
Research Design
Control Groups
Peptides

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation. / Lerman, Amir; Kubo, Spencer H.; Tschumperlin, Linda K.; Burnett, John C Jr.

In: Journal of the American College of Cardiology, Vol. 20, No. 4, 1992, p. 849-853.

Research output: Contribution to journalArticle

@article{6452be6576e24fb691142f7767e7fe62,
title = "Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation",
abstract = "Objectives and Background. Endothelin is an endothelium-derived vasoconstrictor peptide that increases systemic and renal vascular resistance at pathophysiologic concentrations. Recent studies have demonstrated its presence in the circulation and its elevation in animals with congestive heart failure, suggesting that endothelin may contribute to the vasoconstrictive state of heart failure. The current study was designed with two objectives: 1) to demonstrate the elevation or circulating endothelin in patients with heart failure, and 2) to determine the short- and long-term response of endothelin levels after heart transplantation. Methods. Plasma endothelin concentrations were measured in two patient groups. Group 1 included 24 patients with end-stage heart failure who were studied during evaluation for potential heart transplantation. Group 2 included 12 patients from Group 1 who had had heart transplantation. Plasma endothelin concentrations were measured before and on days 1, 3 and 7 after heart transplantation. Eight of these patients also had levels measured 3 to 12 months later. Results. Plasma endothelin concentrations were significantly elevated in patients with heart failure compared with those in an age-matched control group (11.7 ± 1.1 vs. 6.8 ± 0.3 pg/ml). In response to heart transplantation, plasma eadothelin concentrations increased further and were sustained during a long-term follow-up. These later changes were associated with a significant increase in arterial pressure and serum creatinine. Conclusions. This study demonstrates that endothelin concentrations are increased in patients with heart failure and increase further after heart transplantation. It suggests a possible role for endothelin in the cardiovascular and renal adaptive responses to human heart transplantation.",
author = "Amir Lerman and Kubo, {Spencer H.} and Tschumperlin, {Linda K.} and Burnett, {John C Jr.}",
year = "1992",
doi = "10.1016/0735-1097(92)90183-N",
language = "English (US)",
volume = "20",
pages = "849--853",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation

AU - Lerman, Amir

AU - Kubo, Spencer H.

AU - Tschumperlin, Linda K.

AU - Burnett, John C Jr.

PY - 1992

Y1 - 1992

N2 - Objectives and Background. Endothelin is an endothelium-derived vasoconstrictor peptide that increases systemic and renal vascular resistance at pathophysiologic concentrations. Recent studies have demonstrated its presence in the circulation and its elevation in animals with congestive heart failure, suggesting that endothelin may contribute to the vasoconstrictive state of heart failure. The current study was designed with two objectives: 1) to demonstrate the elevation or circulating endothelin in patients with heart failure, and 2) to determine the short- and long-term response of endothelin levels after heart transplantation. Methods. Plasma endothelin concentrations were measured in two patient groups. Group 1 included 24 patients with end-stage heart failure who were studied during evaluation for potential heart transplantation. Group 2 included 12 patients from Group 1 who had had heart transplantation. Plasma endothelin concentrations were measured before and on days 1, 3 and 7 after heart transplantation. Eight of these patients also had levels measured 3 to 12 months later. Results. Plasma endothelin concentrations were significantly elevated in patients with heart failure compared with those in an age-matched control group (11.7 ± 1.1 vs. 6.8 ± 0.3 pg/ml). In response to heart transplantation, plasma eadothelin concentrations increased further and were sustained during a long-term follow-up. These later changes were associated with a significant increase in arterial pressure and serum creatinine. Conclusions. This study demonstrates that endothelin concentrations are increased in patients with heart failure and increase further after heart transplantation. It suggests a possible role for endothelin in the cardiovascular and renal adaptive responses to human heart transplantation.

AB - Objectives and Background. Endothelin is an endothelium-derived vasoconstrictor peptide that increases systemic and renal vascular resistance at pathophysiologic concentrations. Recent studies have demonstrated its presence in the circulation and its elevation in animals with congestive heart failure, suggesting that endothelin may contribute to the vasoconstrictive state of heart failure. The current study was designed with two objectives: 1) to demonstrate the elevation or circulating endothelin in patients with heart failure, and 2) to determine the short- and long-term response of endothelin levels after heart transplantation. Methods. Plasma endothelin concentrations were measured in two patient groups. Group 1 included 24 patients with end-stage heart failure who were studied during evaluation for potential heart transplantation. Group 2 included 12 patients from Group 1 who had had heart transplantation. Plasma endothelin concentrations were measured before and on days 1, 3 and 7 after heart transplantation. Eight of these patients also had levels measured 3 to 12 months later. Results. Plasma endothelin concentrations were significantly elevated in patients with heart failure compared with those in an age-matched control group (11.7 ± 1.1 vs. 6.8 ± 0.3 pg/ml). In response to heart transplantation, plasma eadothelin concentrations increased further and were sustained during a long-term follow-up. These later changes were associated with a significant increase in arterial pressure and serum creatinine. Conclusions. This study demonstrates that endothelin concentrations are increased in patients with heart failure and increase further after heart transplantation. It suggests a possible role for endothelin in the cardiovascular and renal adaptive responses to human heart transplantation.

UR - http://www.scopus.com/inward/record.url?scp=0026460235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026460235&partnerID=8YFLogxK

U2 - 10.1016/0735-1097(92)90183-N

DO - 10.1016/0735-1097(92)90183-N

M3 - Article

C2 - 1527295

AN - SCOPUS:0026460235

VL - 20

SP - 849

EP - 853

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 4

ER -