Plasma cytokines in polycythemia vera: Phenotypic correlates, prognostic relevance, and comparison with myelofibrosis

Rakhee Vaidya, Naseema Gangat, Thitina Jimma, Christy M. Finke, Terra L. Lasho, Animesh Pardanani, Ayalew Tefferi

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Plasma cytokine milieu is abnormal in primary myelofibrosis (PMF) and correlates with disease phenotype and prognosis. In this study, we show that several plasma cytokines are also abnormally expressed in polycythemia vera (PV; n = 65), compared to normal controls (n = 35), but with a significantly different pattern than that of PMF (n = 127). Direct phenotypic correlation in PV included levels of IL-12 with hematocrit; IL-1b, IL-2, IL-7, FGF-b, and HGF with leukocytosis; and IFN-α and IFN-γ with thrombocytosis. In univariate analysis, levels of 13 cytokines (out of 30 analyzed) correlated with survival but only MIP-1β remained significant on multivariable analysis that included the other cytokines as covariates. Increased level of MIP-1β (P < 0.01), older age (P < 0.01), and leukocytosis (P = 0.03) maintained their association with shortened survival, on multivariable analysis. This study provides preliminary observations that warrant a larger scale study and suggests the value of plasma cytokines as prognostic biomarkers in PV.

Original languageEnglish (US)
Pages (from-to)1003-1005
Number of pages3
JournalAmerican journal of hematology
Volume87
Issue number11
DOIs
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • Hematology

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