Plasma C-terminal pro-endothelin-1 is associated with target-organ damage in African Americans with hypertension

Ammar Habib, Malik A. Al-Omari, Mahyar Khaleghi, Nils G. Morgenthaler, Joachim Struck, Andreas Bergmann, Thomas H. Mosley, Stephen T Turner, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

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Abstract

Background Endothelin-1 (ET-1) is a vasoactive peptide with vasoconstrictor and mitogenic properties. We investigated whether plasma levels of C-terminal pro-ET-1 (CT-proET-1), a newly described stable fragment of the ET-1 precursor, are associated with target-organ damage in hypertension.MethodsParticipants included 981 African Americans (65±9 years, 71% women) and 812 non-Hispanic whites (61±9 years, 54% women) ascertained from sibships with hypertension. We measured plasma CT-proET-1 by an immunoluminometric assay. Measures of target-organ damage included the ankle-brachial index (ABI) and urinary albumin:creatinine ratio (UACR). Multivariable regressions analyses were employed to assess whether plasma CT-proET-1 levels were independently associated with ABI and UACR.ResultsIn hypertensive African Americans, higher plasma levels of CT-proET-1 were significantly associated with lower ABI (P 0.01) and higher UACR (P<0.01). After adjustment for age, sex, body mass index, systolic blood pressure (SBP) and diastolic blood pressure (BP), diabetes, serum glucose, insulin use, estimated glomerular filtration rate (eGFR), history of smoking, total and high-density lipoprotein cholesterol, medication use, and previous history of myocardial infarction (MI) or stroke, higher plasma levels of CT-proET-1 remained significantly associated with lower ABI (P<0.01) and higher UACR (P = 0.02). In non-Hispanic white hypertensives, higher plasma levels of CT-proET-1 were weakly associated with higher UACR (P = 0.02) and with lower ABI (P = 0.07). After adjustment for the relevant covariates, no statistically significant associations between CT-proET-1 and ABI or UACR were present in whites.ConclusionsPlasma levels of CT-proET-1 were independently associated with lower ABI and greater UACR in African American but not non-Hispanic white adults with hypertension.

Original languageEnglish (US)
Pages (from-to)1204-1208
Number of pages5
JournalAmerican Journal of Hypertension
Volume23
Issue number11
DOIs
StatePublished - Nov 2010

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Ankle Brachial Index
Endothelin-1
African Americans
Albumins
Creatinine
Hypertension
Blood Pressure
Vasoconstrictor Agents
Glomerular Filtration Rate
HDL Cholesterol
Body Mass Index
Smoking
Stroke
Myocardial Infarction
Regression Analysis
Insulin
Glucose
Peptides
Serum

Keywords

  • ankle-brachial index
  • blood pressure
  • endothelin
  • hypertension
  • target-organ damage
  • urinary albumin:creatinine ratio

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Plasma C-terminal pro-endothelin-1 is associated with target-organ damage in African Americans with hypertension. / Habib, Ammar; Al-Omari, Malik A.; Khaleghi, Mahyar; Morgenthaler, Nils G.; Struck, Joachim; Bergmann, Andreas; Mosley, Thomas H.; Turner, Stephen T; Kullo, Iftikhar Jan.

In: American Journal of Hypertension, Vol. 23, No. 11, 11.2010, p. 1204-1208.

Research output: Contribution to journalArticle

Habib, Ammar ; Al-Omari, Malik A. ; Khaleghi, Mahyar ; Morgenthaler, Nils G. ; Struck, Joachim ; Bergmann, Andreas ; Mosley, Thomas H. ; Turner, Stephen T ; Kullo, Iftikhar Jan. / Plasma C-terminal pro-endothelin-1 is associated with target-organ damage in African Americans with hypertension. In: American Journal of Hypertension. 2010 ; Vol. 23, No. 11. pp. 1204-1208.
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abstract = "Background Endothelin-1 (ET-1) is a vasoactive peptide with vasoconstrictor and mitogenic properties. We investigated whether plasma levels of C-terminal pro-ET-1 (CT-proET-1), a newly described stable fragment of the ET-1 precursor, are associated with target-organ damage in hypertension.MethodsParticipants included 981 African Americans (65±9 years, 71{\%} women) and 812 non-Hispanic whites (61±9 years, 54{\%} women) ascertained from sibships with hypertension. We measured plasma CT-proET-1 by an immunoluminometric assay. Measures of target-organ damage included the ankle-brachial index (ABI) and urinary albumin:creatinine ratio (UACR). Multivariable regressions analyses were employed to assess whether plasma CT-proET-1 levels were independently associated with ABI and UACR.ResultsIn hypertensive African Americans, higher plasma levels of CT-proET-1 were significantly associated with lower ABI (P 0.01) and higher UACR (P<0.01). After adjustment for age, sex, body mass index, systolic blood pressure (SBP) and diastolic blood pressure (BP), diabetes, serum glucose, insulin use, estimated glomerular filtration rate (eGFR), history of smoking, total and high-density lipoprotein cholesterol, medication use, and previous history of myocardial infarction (MI) or stroke, higher plasma levels of CT-proET-1 remained significantly associated with lower ABI (P<0.01) and higher UACR (P = 0.02). In non-Hispanic white hypertensives, higher plasma levels of CT-proET-1 were weakly associated with higher UACR (P = 0.02) and with lower ABI (P = 0.07). After adjustment for the relevant covariates, no statistically significant associations between CT-proET-1 and ABI or UACR were present in whites.ConclusionsPlasma levels of CT-proET-1 were independently associated with lower ABI and greater UACR in African American but not non-Hispanic white adults with hypertension.",
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AU - Al-Omari, Malik A.

AU - Khaleghi, Mahyar

AU - Morgenthaler, Nils G.

AU - Struck, Joachim

AU - Bergmann, Andreas

AU - Mosley, Thomas H.

AU - Turner, Stephen T

AU - Kullo, Iftikhar Jan

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N2 - Background Endothelin-1 (ET-1) is a vasoactive peptide with vasoconstrictor and mitogenic properties. We investigated whether plasma levels of C-terminal pro-ET-1 (CT-proET-1), a newly described stable fragment of the ET-1 precursor, are associated with target-organ damage in hypertension.MethodsParticipants included 981 African Americans (65±9 years, 71% women) and 812 non-Hispanic whites (61±9 years, 54% women) ascertained from sibships with hypertension. We measured plasma CT-proET-1 by an immunoluminometric assay. Measures of target-organ damage included the ankle-brachial index (ABI) and urinary albumin:creatinine ratio (UACR). Multivariable regressions analyses were employed to assess whether plasma CT-proET-1 levels were independently associated with ABI and UACR.ResultsIn hypertensive African Americans, higher plasma levels of CT-proET-1 were significantly associated with lower ABI (P 0.01) and higher UACR (P<0.01). After adjustment for age, sex, body mass index, systolic blood pressure (SBP) and diastolic blood pressure (BP), diabetes, serum glucose, insulin use, estimated glomerular filtration rate (eGFR), history of smoking, total and high-density lipoprotein cholesterol, medication use, and previous history of myocardial infarction (MI) or stroke, higher plasma levels of CT-proET-1 remained significantly associated with lower ABI (P<0.01) and higher UACR (P = 0.02). In non-Hispanic white hypertensives, higher plasma levels of CT-proET-1 were weakly associated with higher UACR (P = 0.02) and with lower ABI (P = 0.07). After adjustment for the relevant covariates, no statistically significant associations between CT-proET-1 and ABI or UACR were present in whites.ConclusionsPlasma levels of CT-proET-1 were independently associated with lower ABI and greater UACR in African American but not non-Hispanic white adults with hypertension.

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