Plasma C-terminal pro-endothelin-1 is associated with left ventricular mass index and aortic root diameter in African-American adults with hypertension

M. A. Al-Omari, M. Khaleghi, T. H. Mosley, N. G. Morgenthaler, J. Struck, A. Bergmann, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Endothelin-1 (ET-1), a circulating vasoactive peptide with potent vasoconstricting and mitogenic properties, may contribute to target-organ damage in hypertension. We investigated whether plasma levels of C-terminal pro-endothelin-1 (CT-pro-ET-1) are associated with left ventricular (LV) mass and aortic root diameter in African-American adults with hypertension. Plasma CT-pro-ET-1 was measured by an immunoluminometric assay in 1041 African Americans (65±9 years, 72% women) with hypertension. LV mass and aortic root diameter were measured according to the American Society of Echocardiography guidelines, and LV mass was indexed by height to the power 2.7 (LVMi). Multivariable regression analyses were used to assess whether plasma CT-pro-ET-1 was associated with LVMi and aortic root diameter, independent of potential confounding variables. Plasma CT-pro-ET-1 was modestly correlated with LVMi (r=0.21, P<0.0001) and aortic root diameter (r=0.09, P=0.004). In separate multivariable regression models that adjusted for age, sex, body mass index, total and high-density lipoprotein cholesterol, smoking history, diabetes, history of myocardial infarction or stroke, and blood pressure-lowering medication and statin use, log CT-pro-ET-1 was significantly associated with greater LVMi (P=0.001) and larger aortic root diameter (P=0.006). CT-pro-ET-1 is independently associated with LVMi and aortic root diameter and may be a marker of target-organ damage in African-Americans adults with hypertension.

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalJournal of Human Hypertension
Volume25
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Endothelin-1
African Americans
Hypertension
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Confounding Factors (Epidemiology)
HDL Cholesterol
Body Mass Index
Smoking
History
Stroke
Myocardial Infarction
Regression Analysis
Guidelines
Blood Pressure
Peptides

Keywords

  • African Americans
  • aortic root diameter
  • endothelin-1
  • left ventricular mass

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Plasma C-terminal pro-endothelin-1 is associated with left ventricular mass index and aortic root diameter in African-American adults with hypertension. / Al-Omari, M. A.; Khaleghi, M.; Mosley, T. H.; Morgenthaler, N. G.; Struck, J.; Bergmann, A.; Kullo, Iftikhar Jan.

In: Journal of Human Hypertension, Vol. 25, No. 2, 02.2011, p. 106-113.

Research output: Contribution to journalArticle

Al-Omari, M. A. ; Khaleghi, M. ; Mosley, T. H. ; Morgenthaler, N. G. ; Struck, J. ; Bergmann, A. ; Kullo, Iftikhar Jan. / Plasma C-terminal pro-endothelin-1 is associated with left ventricular mass index and aortic root diameter in African-American adults with hypertension. In: Journal of Human Hypertension. 2011 ; Vol. 25, No. 2. pp. 106-113.
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