Plasma c-erbB-2 levels in breast cancer patients

Prognostic significance in predicting response to chemotherapy

Rajeshwari R. Mehta, Jannette H. McDermott, Tina J Hieken, Kevin C. Marler, Minu K. Patel, Linda D. Wild, Tapas K. Das Gupta

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Purpose: To determine the significance of plasma c-erbB-2 levels to assess the extent of disease spread and to predict the response to chemotherapy in node-positive breast cancer patients. Methods: We determined plasma levels of c-erbB-2 in 79 stages II and III breast cancer patients who received cyclophosphamide, methotrexate, and flourouracil (CMF)/cyclophosphamide, methotrexate, fluorouracil, vincristine, and prednisone (CMFVP) chemotherapy. All patients had o minimum follow-up of greater than 60 months or until disease recurrence. Plasma samples were obtained before and after chemotherapy. Plasma c-erbB-2 levels were quantified by enzyme-linked immunoassay. c-erbB-2 levels were analyzed in relation to the patients' axillary lymph node status, menopousal status, disease status, disease-free survival (DFS), and steroid receptor status of tumor. Results: Plasma c-erbB-2 levels varied widely in breast cancer patients. In general, when all patients were included in the analyses, plasma c-erbB-2 levels before chemotherapy correlated significantly with the number of positive axillary lymph nodes and with postchemotherapy c-erbB-2 levels. No association was observed between pro- or postchemotherapy c-erbB-2 levels and other variables (patients' age at diagnosis, receptor status of the tumor, or disease status). The prognostic significance of different factors (ie, nodal status [one to three v > three positive nodes], menopausal status [pre- v postmenopausal women), estrogen receptor [ER] status [ER + v ER -], and pre- and postchemotherapy c-erbB-2 levels) in predicting DFS was determined in all study patients. Among the variables examined, nodal status was the strongest predictor of DFS in these patients. The second most significant prognostic marker was postchemotherapy c-erbB-2 level. Prechemotherapy c-erbB-2 levels showed prognostic significance for DFS in a subset of breast cancer patients (ie, patients with > three positive nodes). Patients with greater than three positive lymph nodes and those with greater than 100 fmol/mL of plasma c-erbB-2 levels before therapy had significantly shorter DFS than did those patients with 100 fmol/mL or less c-erbB-2 levels. Conclusion: In breast cancer patients, determination of c-erbB-2 levels before therapy is an important biomarker to assess the extent of disease spread in the lymph nodes. Postchemotherapy c-erbB-2 levels are also a prognostic indicator far DFS in patients who receive chemotherapy. Finally, in a subgroup of patients with greater than three positive nodes, prochemotherapy c-erbB-2 levels are a prognostic marker far response of patients to standard chemotherapy.

Original languageEnglish (US)
Pages (from-to)2409-2416
Number of pages8
JournalJournal of Clinical Oncology
Volume16
Issue number7
StatePublished - Jul 1998
Externally publishedYes

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Breast Neoplasms
Drug Therapy
Disease-Free Survival
Lymph Nodes
Estrogen Receptors
Methotrexate
Cyclophosphamide
Steroid Receptors
Vincristine
Prednisone
Immunoenzyme Techniques
Fluorouracil
Neoplasms
Biomarkers
Recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mehta, R. R., McDermott, J. H., Hieken, T. J., Marler, K. C., Patel, M. K., Wild, L. D., & Das Gupta, T. K. (1998). Plasma c-erbB-2 levels in breast cancer patients: Prognostic significance in predicting response to chemotherapy. Journal of Clinical Oncology, 16(7), 2409-2416.

Plasma c-erbB-2 levels in breast cancer patients : Prognostic significance in predicting response to chemotherapy. / Mehta, Rajeshwari R.; McDermott, Jannette H.; Hieken, Tina J; Marler, Kevin C.; Patel, Minu K.; Wild, Linda D.; Das Gupta, Tapas K.

In: Journal of Clinical Oncology, Vol. 16, No. 7, 07.1998, p. 2409-2416.

Research output: Contribution to journalArticle

Mehta, RR, McDermott, JH, Hieken, TJ, Marler, KC, Patel, MK, Wild, LD & Das Gupta, TK 1998, 'Plasma c-erbB-2 levels in breast cancer patients: Prognostic significance in predicting response to chemotherapy', Journal of Clinical Oncology, vol. 16, no. 7, pp. 2409-2416.
Mehta, Rajeshwari R. ; McDermott, Jannette H. ; Hieken, Tina J ; Marler, Kevin C. ; Patel, Minu K. ; Wild, Linda D. ; Das Gupta, Tapas K. / Plasma c-erbB-2 levels in breast cancer patients : Prognostic significance in predicting response to chemotherapy. In: Journal of Clinical Oncology. 1998 ; Vol. 16, No. 7. pp. 2409-2416.
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title = "Plasma c-erbB-2 levels in breast cancer patients: Prognostic significance in predicting response to chemotherapy",
abstract = "Purpose: To determine the significance of plasma c-erbB-2 levels to assess the extent of disease spread and to predict the response to chemotherapy in node-positive breast cancer patients. Methods: We determined plasma levels of c-erbB-2 in 79 stages II and III breast cancer patients who received cyclophosphamide, methotrexate, and flourouracil (CMF)/cyclophosphamide, methotrexate, fluorouracil, vincristine, and prednisone (CMFVP) chemotherapy. All patients had o minimum follow-up of greater than 60 months or until disease recurrence. Plasma samples were obtained before and after chemotherapy. Plasma c-erbB-2 levels were quantified by enzyme-linked immunoassay. c-erbB-2 levels were analyzed in relation to the patients' axillary lymph node status, menopousal status, disease status, disease-free survival (DFS), and steroid receptor status of tumor. Results: Plasma c-erbB-2 levels varied widely in breast cancer patients. In general, when all patients were included in the analyses, plasma c-erbB-2 levels before chemotherapy correlated significantly with the number of positive axillary lymph nodes and with postchemotherapy c-erbB-2 levels. No association was observed between pro- or postchemotherapy c-erbB-2 levels and other variables (patients' age at diagnosis, receptor status of the tumor, or disease status). The prognostic significance of different factors (ie, nodal status [one to three v > three positive nodes], menopausal status [pre- v postmenopausal women), estrogen receptor [ER] status [ER + v ER -], and pre- and postchemotherapy c-erbB-2 levels) in predicting DFS was determined in all study patients. Among the variables examined, nodal status was the strongest predictor of DFS in these patients. The second most significant prognostic marker was postchemotherapy c-erbB-2 level. Prechemotherapy c-erbB-2 levels showed prognostic significance for DFS in a subset of breast cancer patients (ie, patients with > three positive nodes). Patients with greater than three positive lymph nodes and those with greater than 100 fmol/mL of plasma c-erbB-2 levels before therapy had significantly shorter DFS than did those patients with 100 fmol/mL or less c-erbB-2 levels. Conclusion: In breast cancer patients, determination of c-erbB-2 levels before therapy is an important biomarker to assess the extent of disease spread in the lymph nodes. Postchemotherapy c-erbB-2 levels are also a prognostic indicator far DFS in patients who receive chemotherapy. Finally, in a subgroup of patients with greater than three positive nodes, prochemotherapy c-erbB-2 levels are a prognostic marker far response of patients to standard chemotherapy.",
author = "Mehta, {Rajeshwari R.} and McDermott, {Jannette H.} and Hieken, {Tina J} and Marler, {Kevin C.} and Patel, {Minu K.} and Wild, {Linda D.} and {Das Gupta}, {Tapas K.}",
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T2 - Prognostic significance in predicting response to chemotherapy

AU - Mehta, Rajeshwari R.

AU - McDermott, Jannette H.

AU - Hieken, Tina J

AU - Marler, Kevin C.

AU - Patel, Minu K.

AU - Wild, Linda D.

AU - Das Gupta, Tapas K.

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N2 - Purpose: To determine the significance of plasma c-erbB-2 levels to assess the extent of disease spread and to predict the response to chemotherapy in node-positive breast cancer patients. Methods: We determined plasma levels of c-erbB-2 in 79 stages II and III breast cancer patients who received cyclophosphamide, methotrexate, and flourouracil (CMF)/cyclophosphamide, methotrexate, fluorouracil, vincristine, and prednisone (CMFVP) chemotherapy. All patients had o minimum follow-up of greater than 60 months or until disease recurrence. Plasma samples were obtained before and after chemotherapy. Plasma c-erbB-2 levels were quantified by enzyme-linked immunoassay. c-erbB-2 levels were analyzed in relation to the patients' axillary lymph node status, menopousal status, disease status, disease-free survival (DFS), and steroid receptor status of tumor. Results: Plasma c-erbB-2 levels varied widely in breast cancer patients. In general, when all patients were included in the analyses, plasma c-erbB-2 levels before chemotherapy correlated significantly with the number of positive axillary lymph nodes and with postchemotherapy c-erbB-2 levels. No association was observed between pro- or postchemotherapy c-erbB-2 levels and other variables (patients' age at diagnosis, receptor status of the tumor, or disease status). The prognostic significance of different factors (ie, nodal status [one to three v > three positive nodes], menopausal status [pre- v postmenopausal women), estrogen receptor [ER] status [ER + v ER -], and pre- and postchemotherapy c-erbB-2 levels) in predicting DFS was determined in all study patients. Among the variables examined, nodal status was the strongest predictor of DFS in these patients. The second most significant prognostic marker was postchemotherapy c-erbB-2 level. Prechemotherapy c-erbB-2 levels showed prognostic significance for DFS in a subset of breast cancer patients (ie, patients with > three positive nodes). Patients with greater than three positive lymph nodes and those with greater than 100 fmol/mL of plasma c-erbB-2 levels before therapy had significantly shorter DFS than did those patients with 100 fmol/mL or less c-erbB-2 levels. Conclusion: In breast cancer patients, determination of c-erbB-2 levels before therapy is an important biomarker to assess the extent of disease spread in the lymph nodes. Postchemotherapy c-erbB-2 levels are also a prognostic indicator far DFS in patients who receive chemotherapy. Finally, in a subgroup of patients with greater than three positive nodes, prochemotherapy c-erbB-2 levels are a prognostic marker far response of patients to standard chemotherapy.

AB - Purpose: To determine the significance of plasma c-erbB-2 levels to assess the extent of disease spread and to predict the response to chemotherapy in node-positive breast cancer patients. Methods: We determined plasma levels of c-erbB-2 in 79 stages II and III breast cancer patients who received cyclophosphamide, methotrexate, and flourouracil (CMF)/cyclophosphamide, methotrexate, fluorouracil, vincristine, and prednisone (CMFVP) chemotherapy. All patients had o minimum follow-up of greater than 60 months or until disease recurrence. Plasma samples were obtained before and after chemotherapy. Plasma c-erbB-2 levels were quantified by enzyme-linked immunoassay. c-erbB-2 levels were analyzed in relation to the patients' axillary lymph node status, menopousal status, disease status, disease-free survival (DFS), and steroid receptor status of tumor. Results: Plasma c-erbB-2 levels varied widely in breast cancer patients. In general, when all patients were included in the analyses, plasma c-erbB-2 levels before chemotherapy correlated significantly with the number of positive axillary lymph nodes and with postchemotherapy c-erbB-2 levels. No association was observed between pro- or postchemotherapy c-erbB-2 levels and other variables (patients' age at diagnosis, receptor status of the tumor, or disease status). The prognostic significance of different factors (ie, nodal status [one to three v > three positive nodes], menopausal status [pre- v postmenopausal women), estrogen receptor [ER] status [ER + v ER -], and pre- and postchemotherapy c-erbB-2 levels) in predicting DFS was determined in all study patients. Among the variables examined, nodal status was the strongest predictor of DFS in these patients. The second most significant prognostic marker was postchemotherapy c-erbB-2 level. Prechemotherapy c-erbB-2 levels showed prognostic significance for DFS in a subset of breast cancer patients (ie, patients with > three positive nodes). Patients with greater than three positive lymph nodes and those with greater than 100 fmol/mL of plasma c-erbB-2 levels before therapy had significantly shorter DFS than did those patients with 100 fmol/mL or less c-erbB-2 levels. Conclusion: In breast cancer patients, determination of c-erbB-2 levels before therapy is an important biomarker to assess the extent of disease spread in the lymph nodes. Postchemotherapy c-erbB-2 levels are also a prognostic indicator far DFS in patients who receive chemotherapy. Finally, in a subgroup of patients with greater than three positive nodes, prochemotherapy c-erbB-2 levels are a prognostic marker far response of patients to standard chemotherapy.

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