PLASMA ARGININE VASOPRESSIN IN DEHYDRATED ELDERLY PATIENTS

J. KIRKLAND, M. LYE, C. GODDARD, E. VARGAS, I. DAVIES

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Plasma arginine vasopressin was assessed by radioimmunoassay in dehydrated elderly patients and healthy young and elderly control subjects. The elderly control subjects' AVP levels were higher than the young control subjects (Kruskal‐Wallis rank sums z= 3.29; P <0.001). Despite similar plasma osmolalities, after correction for the osmotic contribution of urea, the patients' AVP levels were higher than the elderly controls (z= 4.16; P <0.001) and were in the range reported to evoke a maximal antidiuretic response. It is concluded that the dehydration which often accompanies acute illness in the elderly is not primarily a consequence of inadequate AVP release.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalClinical Endocrinology
Volume20
Issue number4
DOIs
StatePublished - Apr 1984

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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