Plasma amyloid β protein is elevated in late-onset Alzheimer disease families

Nilufer Taner, L. H. Younkin, D. M. Yager, F. Parfitt, M. C. Baker, S. Asthana, M. L. Hutton, Steven G Younkin, Neill R Graff Radford

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

OBJECTIVE: Plasma Aβ levels are elevated in early-onset Alzheimer disease (AD) caused by autosomal dominant mutations. Our objective was to determine whether similar genetic elevations exist in late-onset AD (LOAD). METHODS: We measured plasma Aβ in first-degree relatives of patients with LOAD in a cross-sectional series and in extended LOAD families. We screened these subjects for pathogenic mutations in early-onset AD genes and determined their ApoE genotypes. RESULTS: Plasma Aβ is significantly elevated in the LOAD first-degree relatives in comparison to unrelated controls and married-in spouses. These elevations are not due to ApoE ϵ4 or pathogenic coding mutations in the known early-onset AD genes. CONCLUSIONS: The findings provide strong evidence for the existence of novel, as yet unknown genetic factors that affect late-onset Alzheimer disease by increasing Aβ.

Original languageEnglish (US)
Pages (from-to)596-606
Number of pages11
JournalNeurology
Volume70
Issue number8
DOIs
StatePublished - Feb 2008

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Amyloidogenic Proteins
Blood Proteins
Alzheimer Disease
Apolipoproteins E
Mutation
Spouses
Genes
Genotype

ASJC Scopus subject areas

  • Neuroscience(all)

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Plasma amyloid β protein is elevated in late-onset Alzheimer disease families. / Taner, Nilufer; Younkin, L. H.; Yager, D. M.; Parfitt, F.; Baker, M. C.; Asthana, S.; Hutton, M. L.; Younkin, Steven G; Graff Radford, Neill R.

In: Neurology, Vol. 70, No. 8, 02.2008, p. 596-606.

Research output: Contribution to journalArticle

Taner, Nilufer ; Younkin, L. H. ; Yager, D. M. ; Parfitt, F. ; Baker, M. C. ; Asthana, S. ; Hutton, M. L. ; Younkin, Steven G ; Graff Radford, Neill R. / Plasma amyloid β protein is elevated in late-onset Alzheimer disease families. In: Neurology. 2008 ; Vol. 70, No. 8. pp. 596-606.
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AU - Yager, D. M.

AU - Parfitt, F.

AU - Baker, M. C.

AU - Asthana, S.

AU - Hutton, M. L.

AU - Younkin, Steven G

AU - Graff Radford, Neill R

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