Plasma Adrenomedullin and Obstructive Sleep Apnea

Robert Wolk, Anna Svatikova, Maria E. Otto, Michal S. Hoffmann, Carolyn J. Duenwald, Virend Somers

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Obstructive sleep apnea (OSA) is associated with hypertension. The vasorelaxing peptide adrenomedullin (ADM) may counteract effects of OSA-induced release of vasopressor substances. Methods: Plasma ADM levels were measured at 9:30 PM, 2:00 AM (after 4 to 5 h of untreated OSA), and 6:00 AM (after 4 h of continuous positive airway pressure treatment) in 15 OSA patients and in 10 controls. Results: Baseline ADM levels were similar in the OSA and control groups (28.7 ± 6.7 v 27.7 ± 6.4 pg/mL, respectively), did not change overnight in either group, and were not affected by continuous positive airway pressure. Conclusions: OSA does not exert any significant acute or chronic effects on plasma ADM levels.

Original languageEnglish (US)
Pages (from-to)74-76
Number of pages3
JournalAmerican Journal of Hypertension
Volume17
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Adrenomedullin
Obstructive Sleep Apnea
Continuous Positive Airway Pressure
Hypertension
Control Groups
Peptides

Keywords

  • Adrenomedullin
  • Continuous positive airway pressure
  • Sleep apnea

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Wolk, R., Svatikova, A., Otto, M. E., Hoffmann, M. S., Duenwald, C. J., & Somers, V. (2004). Plasma Adrenomedullin and Obstructive Sleep Apnea. American Journal of Hypertension, 17(1), 74-76. https://doi.org/10.1016/j.amjhyper.2003.09.004

Plasma Adrenomedullin and Obstructive Sleep Apnea. / Wolk, Robert; Svatikova, Anna; Otto, Maria E.; Hoffmann, Michal S.; Duenwald, Carolyn J.; Somers, Virend.

In: American Journal of Hypertension, Vol. 17, No. 1, 01.2004, p. 74-76.

Research output: Contribution to journalArticle

Wolk, R, Svatikova, A, Otto, ME, Hoffmann, MS, Duenwald, CJ & Somers, V 2004, 'Plasma Adrenomedullin and Obstructive Sleep Apnea', American Journal of Hypertension, vol. 17, no. 1, pp. 74-76. https://doi.org/10.1016/j.amjhyper.2003.09.004
Wolk, Robert ; Svatikova, Anna ; Otto, Maria E. ; Hoffmann, Michal S. ; Duenwald, Carolyn J. ; Somers, Virend. / Plasma Adrenomedullin and Obstructive Sleep Apnea. In: American Journal of Hypertension. 2004 ; Vol. 17, No. 1. pp. 74-76.
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