Abstract
Background: Obstructive sleep apnea (OSA) is associated with hypertension. The vasorelaxing peptide adrenomedullin (ADM) may counteract effects of OSA-induced release of vasopressor substances. Methods: Plasma ADM levels were measured at 9:30 PM, 2:00 AM (after 4 to 5 h of untreated OSA), and 6:00 AM (after 4 h of continuous positive airway pressure treatment) in 15 OSA patients and in 10 controls. Results: Baseline ADM levels were similar in the OSA and control groups (28.7 ± 6.7 v 27.7 ± 6.4 pg/mL, respectively), did not change overnight in either group, and were not affected by continuous positive airway pressure. Conclusions: OSA does not exert any significant acute or chronic effects on plasma ADM levels.
Original language | English (US) |
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Pages (from-to) | 74-76 |
Number of pages | 3 |
Journal | American journal of hypertension |
Volume | 17 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2004 |
Keywords
- Adrenomedullin
- Continuous positive airway pressure
- Sleep apnea
ASJC Scopus subject areas
- Internal Medicine