Plasma 8-iso-prostaglandin F, a marker of oxidative stress, is increased in patients with acute myocardial infarction

Ahmad A. Elesber, Patricia Best, Ryan J. Lennon, Verghese Mathew, Charanjit S. Rihal, Lilach O Lerman, Amir Lerman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction. Methods: Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n =15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13). Results: Plasma 8-iso-prostaglandin F levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 ± 73.9 pg/ml) as compared to patients with stable CAD (182.0 + 75.7 pg/ml) and patients with no significant CAD (118.9 ± 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level. Conclusion: Plasma 8-iso-prostaglandin F levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalFree Radical Research
Volume40
Issue number4
DOIs
StatePublished - Apr 2006

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Oxidative stress
Dinoprost
Oxidative Stress
Myocardial Infarction
Plasmas
Coronary Artery Disease
Atherosclerosis
C-Reactive Protein

Keywords

  • Artherosclerosis
  • Isoprostanes
  • Myocardial infarction
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry

Cite this

Plasma 8-iso-prostaglandin F, a marker of oxidative stress, is increased in patients with acute myocardial infarction. / Elesber, Ahmad A.; Best, Patricia; Lennon, Ryan J.; Mathew, Verghese; Rihal, Charanjit S.; Lerman, Lilach O; Lerman, Amir.

In: Free Radical Research, Vol. 40, No. 4, 04.2006, p. 385-391.

Research output: Contribution to journalArticle

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abstract = "Background: Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F2α level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction. Methods: Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n =15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13). Results: Plasma 8-iso-prostaglandin F2α levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 ± 73.9 pg/ml) as compared to patients with stable CAD (182.0 + 75.7 pg/ml) and patients with no significant CAD (118.9 ± 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level. Conclusion: Plasma 8-iso-prostaglandin F2α levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction.",
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AU - Best, Patricia

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AU - Mathew, Verghese

AU - Rihal, Charanjit S.

AU - Lerman, Lilach O

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AB - Background: Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F2α level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction. Methods: Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n =15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13). Results: Plasma 8-iso-prostaglandin F2α levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 ± 73.9 pg/ml) as compared to patients with stable CAD (182.0 + 75.7 pg/ml) and patients with no significant CAD (118.9 ± 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level. Conclusion: Plasma 8-iso-prostaglandin F2α levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction.

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