Plasma 8-iso-prostaglandin F, a marker of oxidative stress, is increased in patients with acute myocardial infarction

Ahmad A. Elesber, Patricia J. Best, Ryan J. Lennon, Verghese Mathew, Charanjit S. Rihal, Lilach O. Lerman, Amir Lerman

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction. Methods: Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n =15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13). Results: Plasma 8-iso-prostaglandin F levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 ± 73.9 pg/ml) as compared to patients with stable CAD (182.0 + 75.7 pg/ml) and patients with no significant CAD (118.9 ± 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level. Conclusion: Plasma 8-iso-prostaglandin F levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalFree Radical Research
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2006

Keywords

  • Artherosclerosis
  • Isoprostanes
  • Myocardial infarction
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry

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