Plasma α‐Amino‐n‐Butyric Acid/Leucine Ratio in Alcoholics

James D. Jones; Robert M. Morse; Richard D. Hurt

doi:10.1111/j.1530-0277.1981.tb04917.x

Plasma α‐Amino‐n‐Butyric Acid/Leucine Ratio in Alcoholics

James D. Jones, Robert M. Morse, Richard D. Hurt

Primary Care Internal Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Fasting free amino acid concentrations in plasma of 20 control and 18 alcoholic subjects were compared in an attempt to validate previous reports that the molar ratio of α‐amino‐n‐butyric acid/leucine (A/L ratio) is a marker for alcoholism. We were unable to confirm the observations of either altered α‐amino‐n‐butyric acid or leucine concentrations or an increased A/L ratio in alcoholic subjects, and we conclude that the A/L ratio is not a biochemical marker for alcoholism.

Original language	English (US)
Pages (from-to)	363-365
Number of pages	3
Journal	Alcoholism: Clinical and Experimental Research
Volume	5
Issue number	3
DOIs	https://doi.org/10.1111/j.1530-0277.1981.tb04917.x
State	Published - Jun 1981

ASJC Scopus subject areas

Medicine (miscellaneous)
Toxicology
Psychiatry and Mental health

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10.1111/j.1530-0277.1981.tb04917.x

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N2 - Fasting free amino acid concentrations in plasma of 20 control and 18 alcoholic subjects were compared in an attempt to validate previous reports that the molar ratio of α‐amino‐n‐butyric acid/leucine (A/L ratio) is a marker for alcoholism. We were unable to confirm the observations of either altered α‐amino‐n‐butyric acid or leucine concentrations or an increased A/L ratio in alcoholic subjects, and we conclude that the A/L ratio is not a biochemical marker for alcoholism.

AB - Fasting free amino acid concentrations in plasma of 20 control and 18 alcoholic subjects were compared in an attempt to validate previous reports that the molar ratio of α‐amino‐n‐butyric acid/leucine (A/L ratio) is a marker for alcoholism. We were unable to confirm the observations of either altered α‐amino‐n‐butyric acid or leucine concentrations or an increased A/L ratio in alcoholic subjects, and we conclude that the A/L ratio is not a biochemical marker for alcoholism.

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Plasma α‐Amino‐n‐Butyric Acid/Leucine Ratio in Alcoholics

Abstract

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