PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

Yotaro Kudo, Masayuki Sugimoto, Esperanza Arias, Hiroaki Kasashima, Thekla Cordes, Juan F. Linares, Angeles Duran, Yuki Nakanishi, Naoko Nakanishi, Antoine L'Hermitte, Alex Campos, Nadia Senni, Tarmo Rooslid, Lewis R. Roberts, Ana Maria Cuervo, Christian M. Metallo, Michael Karin, Maria T. Diaz-Meco, Jorge Moscat

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Yotaro et al. define a tumor suppressor role for PKCλ/ι in hepatocellular carcinoma (HCC). PKCλ/ι loss induces oxidative phosphorylation, reactive oxygen species production, and autophagy. These events activate an NRF2 transcriptional program that supports HCC progression.

Original languageEnglish (US)
Pages (from-to)247-262.e11
JournalCancer cell
Volume38
Issue number2
DOIs
StatePublished - Aug 10 2020

Keywords

  • NRF2
  • PKCζ
  • PKCι
  • PKCλ
  • atypical PKC
  • autophagy
  • hepatocellular carcinoma
  • metabolic reprogramming
  • oxidative phosphorylation
  • reactive oxygen species

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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  • Cite this

    Kudo, Y., Sugimoto, M., Arias, E., Kasashima, H., Cordes, T., Linares, J. F., Duran, A., Nakanishi, Y., Nakanishi, N., L'Hermitte, A., Campos, A., Senni, N., Rooslid, T., Roberts, L. R., Cuervo, A. M., Metallo, C. M., Karin, M., Diaz-Meco, M. T., & Moscat, J. (2020). PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer cell, 38(2), 247-262.e11. https://doi.org/10.1016/j.ccell.2020.05.018