PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

Yotaro Kudo; Masayuki Sugimoto; Esperanza Arias; Hiroaki Kasashima; Thekla Cordes; Juan F. Linares; Angeles Duran; Yuki Nakanishi; Naoko Nakanishi; Antoine L'Hermitte; Alex Campos; Nadia Senni; Tarmo Rooslid; Lewis R. Roberts; Ana Maria Cuervo; Christian M. Metallo; Michael Karin; Maria T. Diaz-Meco; Jorge Moscat

doi:10.1016/j.ccell.2020.05.018

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

Yotaro Kudo, Masayuki Sugimoto, Esperanza Arias, Hiroaki Kasashima, Thekla Cordes, Juan F. Linares, Angeles Duran, Yuki Nakanishi, Naoko Nakanishi, Antoine L'Hermitte, Alex Campos, Nadia Senni, Tarmo Rooslid, Lewis R. Roberts, Ana Maria Cuervo, Christian M. Metallo, Michael Karin, Maria T. Diaz-Meco, Jorge Moscat

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Yotaro et al. define a tumor suppressor role for PKCλ/ι in hepatocellular carcinoma (HCC). PKCλ/ι loss induces oxidative phosphorylation, reactive oxygen species production, and autophagy. These events activate an NRF2 transcriptional program that supports HCC progression.

Original language	English (US)
Pages (from-to)	247-262.e11
Journal	Cancer cell
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.ccell.2020.05.018
State	Published - Aug 10 2020

Keywords

NRF2
PKCζ
PKCι
PKCλ
atypical PKC
autophagy
hepatocellular carcinoma
metabolic reprogramming
oxidative phosphorylation
reactive oxygen species

ASJC Scopus subject areas

Oncology
Cancer Research

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Kudo, Y., Sugimoto, M., Arias, E., Kasashima, H., Cordes, T., Linares, J. F., Duran, A., Nakanishi, Y., Nakanishi, N., L'Hermitte, A., Campos, A., Senni, N., Rooslid, T., Roberts, L. R., Cuervo, A. M., Metallo, C. M., Karin, M., Diaz-Meco, M. T., & Moscat, J. (2020). PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer cell, 38(2), 247-262.e11. https://doi.org/10.1016/j.ccell.2020.05.018

Kudo, Y, Sugimoto, M, Arias, E, Kasashima, H, Cordes, T, Linares, JF, Duran, A, Nakanishi, Y, Nakanishi, N, L'Hermitte, A, Campos, A, Senni, N, Rooslid, T, Roberts, LR, Cuervo, AM, Metallo, CM, Karin, M, Diaz-Meco, MT & Moscat, J 2020, 'PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression', Cancer cell, vol. 38, no. 2, pp. 247-262.e11. https://doi.org/10.1016/j.ccell.2020.05.018

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title = "PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression",

abstract = "Yotaro et al. define a tumor suppressor role for PKCλ/ι in hepatocellular carcinoma (HCC). PKCλ/ι loss induces oxidative phosphorylation, reactive oxygen species production, and autophagy. These events activate an NRF2 transcriptional program that supports HCC progression.",

keywords = "NRF2, PKCζ, PKCι, PKCλ, atypical PKC, autophagy, hepatocellular carcinoma, metabolic reprogramming, oxidative phosphorylation, reactive oxygen species",

author = "Yotaro Kudo and Masayuki Sugimoto and Esperanza Arias and Hiroaki Kasashima and Thekla Cordes and Linares, {Juan F.} and Angeles Duran and Yuki Nakanishi and Naoko Nakanishi and Antoine L'Hermitte and Alex Campos and Nadia Senni and Tarmo Rooslid and Roberts, {Lewis R.} and Cuervo, {Ana Maria} and Metallo, {Christian M.} and Michael Karin and Diaz-Meco, {Maria T.} and Jorge Moscat",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

day = "10",

doi = "10.1016/j.ccell.2020.05.018",

language = "English (US)",

volume = "38",

pages = "247--262.e11",

journal = "Cancer cell",

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T1 - PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

AU - Kudo, Yotaro

AU - Sugimoto, Masayuki

AU - Arias, Esperanza

AU - Kasashima, Hiroaki

AU - Cordes, Thekla

AU - Linares, Juan F.

AU - Duran, Angeles

AU - Nakanishi, Yuki

AU - Nakanishi, Naoko

AU - L'Hermitte, Antoine

AU - Campos, Alex

AU - Senni, Nadia

AU - Rooslid, Tarmo

AU - Roberts, Lewis R.

AU - Cuervo, Ana Maria

AU - Metallo, Christian M.

AU - Karin, Michael

AU - Diaz-Meco, Maria T.

AU - Moscat, Jorge

PY - 2020/8/10

Y1 - 2020/8/10

N2 - Yotaro et al. define a tumor suppressor role for PKCλ/ι in hepatocellular carcinoma (HCC). PKCλ/ι loss induces oxidative phosphorylation, reactive oxygen species production, and autophagy. These events activate an NRF2 transcriptional program that supports HCC progression.

AB - Yotaro et al. define a tumor suppressor role for PKCλ/ι in hepatocellular carcinoma (HCC). PKCλ/ι loss induces oxidative phosphorylation, reactive oxygen species production, and autophagy. These events activate an NRF2 transcriptional program that supports HCC progression.

KW - NRF2

KW - PKCζ

KW - PKCι

KW - PKCλ

KW - atypical PKC

KW - autophagy

KW - hepatocellular carcinoma

KW - metabolic reprogramming

KW - oxidative phosphorylation

KW - reactive oxygen species

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M3 - Article

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AN - SCOPUS:85087725816

SN - 1535-6108

VL - 38

SP - 247-262.e11

JO - Cancer cell

JF - Cancer cell

IS - 2

ER -

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

Abstract

Keywords

ASJC Scopus subject areas

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