PJ3-050 Effects of Obstructive Sleep Apnea on Cardiac Sympathetic Drive during Sleep in Patients after Myocardial Infarction

Taro Adachi, Fatima Sert-Kuniyoshi, Andrew D. Calvin, Christelle van der Walt, Jan Bukartyk, Apoor_S Gami, Youichi Kobayashi, Virend Somers

Research output: Contribution to journalArticle

Abstract

Observational data suggest sudden cardiac death is more likely to occur during sleep in patients with obstructive sleep apnea (OSA). Sleep-related autonomic abnormalities may be implicated. We hypothesized that the presence of OSA is associated with increased cardiac sympathetic drive during sleep in patients after myocardial infarction (MI).We conducted a cross-sectional study of patients (n=40) within 1 to 3 months after MI. The presence of OSA was determined by polysomnography. Spectral analysis was performed 5-minute periods of stable ventilation during both REM sleep and non-REM sleep (stage 3 and 4). The LF/HF ratio was calculated to reflect sympathovagal balance.Mean age of study participants was 58 ±10 years, 83% were men and 95% were taking β-blockers. OSA was present in 60% of the patients. The LF/HF ratio was higher in patients with OSA during both non-REM (6.5±7.6 vs. 2.7±1.8, p=0.02) and REM sleep (6.4±5.4 vs. 3.9±3.3, p=0.03).OSA is accompanied by an altered cardiac sympathovagal balance favoring heightened sympathetic drive during both non-REM and REM sleep in patients after MI. This might contribute to the increased risk of sudden cardiac death during sleep in patients with OSA, and may be associated with poorer prognosis in this patient population.

Original languageEnglish (US)
JournalJournal of Arrhythmia
Volume27
DOIs
StatePublished - 2011

Fingerprint

Obstructive Sleep Apnea
Sleep
Myocardial Infarction
REM Sleep
Sudden Cardiac Death
Drive
Polysomnography
Sleep Stages
Ventilation
Cross-Sectional Studies
Population

Keywords

  • heart rate variability
  • myocardial infarction
  • obstructive sleep apnea

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

PJ3-050 Effects of Obstructive Sleep Apnea on Cardiac Sympathetic Drive during Sleep in Patients after Myocardial Infarction. / Adachi, Taro; Sert-Kuniyoshi, Fatima; Calvin, Andrew D.; van der Walt, Christelle; Bukartyk, Jan; Gami, Apoor_S; Kobayashi, Youichi; Somers, Virend.

In: Journal of Arrhythmia, Vol. 27, 2011.

Research output: Contribution to journalArticle

Adachi, Taro ; Sert-Kuniyoshi, Fatima ; Calvin, Andrew D. ; van der Walt, Christelle ; Bukartyk, Jan ; Gami, Apoor_S ; Kobayashi, Youichi ; Somers, Virend. / PJ3-050 Effects of Obstructive Sleep Apnea on Cardiac Sympathetic Drive during Sleep in Patients after Myocardial Infarction. In: Journal of Arrhythmia. 2011 ; Vol. 27.
@article{10d3e9936225492db8457006325a30e2,
title = "PJ3-050 Effects of Obstructive Sleep Apnea on Cardiac Sympathetic Drive during Sleep in Patients after Myocardial Infarction",
abstract = "Observational data suggest sudden cardiac death is more likely to occur during sleep in patients with obstructive sleep apnea (OSA). Sleep-related autonomic abnormalities may be implicated. We hypothesized that the presence of OSA is associated with increased cardiac sympathetic drive during sleep in patients after myocardial infarction (MI).We conducted a cross-sectional study of patients (n=40) within 1 to 3 months after MI. The presence of OSA was determined by polysomnography. Spectral analysis was performed 5-minute periods of stable ventilation during both REM sleep and non-REM sleep (stage 3 and 4). The LF/HF ratio was calculated to reflect sympathovagal balance.Mean age of study participants was 58 ±10 years, 83{\%} were men and 95{\%} were taking β-blockers. OSA was present in 60{\%} of the patients. The LF/HF ratio was higher in patients with OSA during both non-REM (6.5±7.6 vs. 2.7±1.8, p=0.02) and REM sleep (6.4±5.4 vs. 3.9±3.3, p=0.03).OSA is accompanied by an altered cardiac sympathovagal balance favoring heightened sympathetic drive during both non-REM and REM sleep in patients after MI. This might contribute to the increased risk of sudden cardiac death during sleep in patients with OSA, and may be associated with poorer prognosis in this patient population.",
keywords = "heart rate variability, myocardial infarction, obstructive sleep apnea",
author = "Taro Adachi and Fatima Sert-Kuniyoshi and Calvin, {Andrew D.} and {van der Walt}, Christelle and Jan Bukartyk and Apoor_S Gami and Youichi Kobayashi and Virend Somers",
year = "2011",
doi = "10.4020/jhrs.27.PJ3_050",
language = "English (US)",
volume = "27",
journal = "Journal of Arrhythmia",
issn = "1880-4276",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - PJ3-050 Effects of Obstructive Sleep Apnea on Cardiac Sympathetic Drive during Sleep in Patients after Myocardial Infarction

AU - Adachi, Taro

AU - Sert-Kuniyoshi, Fatima

AU - Calvin, Andrew D.

AU - van der Walt, Christelle

AU - Bukartyk, Jan

AU - Gami, Apoor_S

AU - Kobayashi, Youichi

AU - Somers, Virend

PY - 2011

Y1 - 2011

N2 - Observational data suggest sudden cardiac death is more likely to occur during sleep in patients with obstructive sleep apnea (OSA). Sleep-related autonomic abnormalities may be implicated. We hypothesized that the presence of OSA is associated with increased cardiac sympathetic drive during sleep in patients after myocardial infarction (MI).We conducted a cross-sectional study of patients (n=40) within 1 to 3 months after MI. The presence of OSA was determined by polysomnography. Spectral analysis was performed 5-minute periods of stable ventilation during both REM sleep and non-REM sleep (stage 3 and 4). The LF/HF ratio was calculated to reflect sympathovagal balance.Mean age of study participants was 58 ±10 years, 83% were men and 95% were taking β-blockers. OSA was present in 60% of the patients. The LF/HF ratio was higher in patients with OSA during both non-REM (6.5±7.6 vs. 2.7±1.8, p=0.02) and REM sleep (6.4±5.4 vs. 3.9±3.3, p=0.03).OSA is accompanied by an altered cardiac sympathovagal balance favoring heightened sympathetic drive during both non-REM and REM sleep in patients after MI. This might contribute to the increased risk of sudden cardiac death during sleep in patients with OSA, and may be associated with poorer prognosis in this patient population.

AB - Observational data suggest sudden cardiac death is more likely to occur during sleep in patients with obstructive sleep apnea (OSA). Sleep-related autonomic abnormalities may be implicated. We hypothesized that the presence of OSA is associated with increased cardiac sympathetic drive during sleep in patients after myocardial infarction (MI).We conducted a cross-sectional study of patients (n=40) within 1 to 3 months after MI. The presence of OSA was determined by polysomnography. Spectral analysis was performed 5-minute periods of stable ventilation during both REM sleep and non-REM sleep (stage 3 and 4). The LF/HF ratio was calculated to reflect sympathovagal balance.Mean age of study participants was 58 ±10 years, 83% were men and 95% were taking β-blockers. OSA was present in 60% of the patients. The LF/HF ratio was higher in patients with OSA during both non-REM (6.5±7.6 vs. 2.7±1.8, p=0.02) and REM sleep (6.4±5.4 vs. 3.9±3.3, p=0.03).OSA is accompanied by an altered cardiac sympathovagal balance favoring heightened sympathetic drive during both non-REM and REM sleep in patients after MI. This might contribute to the increased risk of sudden cardiac death during sleep in patients with OSA, and may be associated with poorer prognosis in this patient population.

KW - heart rate variability

KW - myocardial infarction

KW - obstructive sleep apnea

UR - http://www.scopus.com/inward/record.url?scp=85008731556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008731556&partnerID=8YFLogxK

U2 - 10.4020/jhrs.27.PJ3_050

DO - 10.4020/jhrs.27.PJ3_050

M3 - Article

AN - SCOPUS:85008731556

VL - 27

JO - Journal of Arrhythmia

JF - Journal of Arrhythmia

SN - 1880-4276

ER -