Pituitary thyrotropic adenoma associated with congenital hypothyroidism. Report of two cases

Vahab Fatourechi, Hossein Gharib, Bernd W. Scheithauer, Nematolah A. Meybody, Mohsen Gharib

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Abstract

Two patients with congenital hypothyroidism and thyroid-stimulating hormone-secreting pituitary adenomas are described. Both patients had a history of long-standing, inadequately treated hypothyroidism accompanied by markedly elevated levels of serum thyroid-stimulating hormone. Pituitary tissue, obtained at autopsy In the first patient and at surgery in the second, disclosed a thyrotropic adenoma. Immunocytochemlcal studies with anti-thyroid-stimulating hormone antisera showed both tumors to be strongly immunoreactive. Such thyrotropic adenomas of the pituitary gland are presumed to occur as the result of protracted pituitary stimulation secondary to long-standing thyroid deficiency.

Original languageEnglish (US)
Pages (from-to)725-728
Number of pages4
JournalThe American Journal of Medicine
Volume76
Issue number4
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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