Pituitary dwarfism in mice persistently infected with lymphocytic choriomeningitis virus

M. Rodriguez, R. J. von Wedel, R. S. Garrett, P. W. Lampert, M. B. Oldstone

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Most strains of mice injected intracerebrally with lymphocytic choriomeningitis virus grow to adulthood maintaining a persistent virus infection associated with chronic virus-induced immune complex disease. However, mice on a k background are highly susceptible to neonatal infection and develop the clinical syndrome of pituitary dwarfism and hypoglycemia. Examination of pituitary tissue fails to reveal morphologic alteration by light and electron microscopy. Within the pituitary, viral antigens are exclusively distributed within the cells of the adenohypophysis. Using ultrastructural colloidal gold-labeling techniques, we demonstrate the presence of mature virus particles budding from the surface of growth hormone containing cells from the pituitary. This study indicates that persistent lymphocytic choriomeningitis virus infection of the growth hormone cells in susceptible mice is associated with pituitary dwarfism without producing visible structural damage.

Original languageEnglish (US)
Pages (from-to)48-53
Number of pages6
JournalLaboratory Investigation
Volume49
Issue number1
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Rodriguez, M., von Wedel, R. J., Garrett, R. S., Lampert, P. W., & Oldstone, M. B. (1983). Pituitary dwarfism in mice persistently infected with lymphocytic choriomeningitis virus. Laboratory Investigation, 49(1), 48-53.