Pituitary adenoma with tumoral granulomatous reaction

Bernd W. Scheithauer, Ana Isabel Silva, John L.D. Atkinson, Todd B. Nippoldt, Timothy J. Kaufmann, Kalman Kovacs, Eva Horvath, Ricardo Lloyd

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalEndocrine Pathology
Volume18
Issue number2
DOIs
StatePublished - Jun 1 2007

Keywords

  • Granuloma
  • Inflammation
  • Pituitary
  • Silent corticotroph adenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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  • Cite this

    Scheithauer, B. W., Silva, A. I., Atkinson, J. L. D., Nippoldt, T. B., Kaufmann, T. J., Kovacs, K., Horvath, E., & Lloyd, R. (2007). Pituitary adenoma with tumoral granulomatous reaction. Endocrine Pathology, 18(2), 86-90. https://doi.org/10.1007/s12022-007-0017-5