Pituitary adenoma with tumoral granulomatous reaction

Bernd W. Scheithauer; Ana Isabel Silva; John L.D. Atkinson; Todd B. Nippoldt; Timothy J. Kaufmann; Kalman Kovacs; Eva Horvath; Ricardo Lloyd

doi:10.1007/s12022-007-0017-5

Pituitary adenoma with tumoral granulomatous reaction

Bernd W. Scheithauer, Ana Isabel Silva, John L.D. Atkinson, Todd B. Nippoldt, Timothy J. Kaufmann, Kalman Kovacs, Eva Horvath, Ricardo Lloyd

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.

Original language	English (US)
Pages (from-to)	86-90
Number of pages	5
Journal	Endocrine Pathology
Volume	18
Issue number	2
DOIs	https://doi.org/10.1007/s12022-007-0017-5
State	Published - Jun 2007

Keywords

Granuloma
Inflammation
Pituitary
Silent corticotroph adenoma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/s12022-007-0017-5

Cite this

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title = "Pituitary adenoma with tumoral granulomatous reaction",

abstract = "Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.",

keywords = "Granuloma, Inflammation, Pituitary, Silent corticotroph adenoma",

author = "Scheithauer, {Bernd W.} and Silva, {Ana Isabel} and Atkinson, {John L.D.} and Nippoldt, {Todd B.} and Kaufmann, {Timothy J.} and Kalman Kovacs and Eva Horvath and Ricardo Lloyd",

note = "Funding Information: Acknowledgment The authors express their appreciation to Seanne P. Buckwalter, M.S. and Dr. Nancy L. Wengenack of the Division of Microbiology, Mayo Clinic, for performance of PCR reactions and to Mr. and Mrs. Jarislowsky and the Lloyd Carr-Harris Foundations for their generous financial support. We also acknowledge the expert secretarial support of Mrs. Denise Chase.",

year = "2007",

month = jun,

doi = "10.1007/s12022-007-0017-5",

language = "English (US)",

volume = "18",

pages = "86--90",

journal = "Endocrine Pathology",

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publisher = "Humana Press",

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T1 - Pituitary adenoma with tumoral granulomatous reaction

AU - Scheithauer, Bernd W.

AU - Silva, Ana Isabel

AU - Atkinson, John L.D.

AU - Nippoldt, Todd B.

AU - Kaufmann, Timothy J.

AU - Kovacs, Kalman

AU - Horvath, Eva

AU - Lloyd, Ricardo

N1 - Funding Information: Acknowledgment The authors express their appreciation to Seanne P. Buckwalter, M.S. and Dr. Nancy L. Wengenack of the Division of Microbiology, Mayo Clinic, for performance of PCR reactions and to Mr. and Mrs. Jarislowsky and the Lloyd Carr-Harris Foundations for their generous financial support. We also acknowledge the expert secretarial support of Mrs. Denise Chase.

PY - 2007/6

Y1 - 2007/6

N2 - Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.

AB - Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.

KW - Granuloma

KW - Inflammation

KW - Pituitary

KW - Silent corticotroph adenoma

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JF - Endocrine Pathology

IS - 2

ER -

Pituitary adenoma with tumoral granulomatous reaction

Abstract

Keywords

ASJC Scopus subject areas

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