TY - JOUR
T1 - Pituitary adenoma in Carney complex
T2 - An immunohistochemical, ultrastructural, and immunoelectron microscopic study
AU - Kurtkaya-Yapicier, Ö
AU - Scheithauer, B. W.
AU - Carney, J. A.
AU - Kovacs, K.
AU - Horvath, E.
AU - Stratakis, C. A.
AU - Vidal, S.
AU - Vella, A.
AU - Young, W. F.
AU - Atkinson, J. L.D.
AU - Lloyd, R. V.
AU - Kontogeorgos, G.
PY - 2002/11
Y1 - 2002/11
N2 - First described in 1985, Carney complex is a rare, heritable disorder featuring abnormal skin pigmentation, cardiac and cutaneous myxoma, melanotic schwannoma of psammomatous type, and endocrine abnormalities, including pituitary adenomas. Patients with the latter present with elevated growth hormone (GH) levels and acromegaly or gigantism. Prolactin (PRL) elevation may also be seen. The authors have investigated 2 resected pituitary adenomas from patients with Carney complex. One, a 19-year-old female acromegalic with elevated GH, IgF-1, and PRL levels, had a mammosomatotroph adenoma immunoreactive for GH and PRL. Ultrastructurally, GH and PRL were present in the same secretory granules. The second patient, a 27-year-old acromegalic, had a sparsely granulated GH cell adenoma that by immuno-electron microscopy revealed GH immunoreactivity only. The lack of morphologic similarity between the 2 adenomas indicates that pituitary tumors in patients with Carney complex may not exhibit the same phenotype.
AB - First described in 1985, Carney complex is a rare, heritable disorder featuring abnormal skin pigmentation, cardiac and cutaneous myxoma, melanotic schwannoma of psammomatous type, and endocrine abnormalities, including pituitary adenomas. Patients with the latter present with elevated growth hormone (GH) levels and acromegaly or gigantism. Prolactin (PRL) elevation may also be seen. The authors have investigated 2 resected pituitary adenomas from patients with Carney complex. One, a 19-year-old female acromegalic with elevated GH, IgF-1, and PRL levels, had a mammosomatotroph adenoma immunoreactive for GH and PRL. Ultrastructurally, GH and PRL were present in the same secretory granules. The second patient, a 27-year-old acromegalic, had a sparsely granulated GH cell adenoma that by immuno-electron microscopy revealed GH immunoreactivity only. The lack of morphologic similarity between the 2 adenomas indicates that pituitary tumors in patients with Carney complex may not exhibit the same phenotype.
KW - Carney complex
KW - Immunoelectron microscopy
KW - Pituitary adenoma
KW - Ultrastructure
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U2 - 10.1080/01913120290104656
DO - 10.1080/01913120290104656
M3 - Article
C2 - 12537759
AN - SCOPUS:12244284607
SN - 0191-3123
VL - 26
SP - 345
EP - 353
JO - Ultrastructural Pathology
JF - Ultrastructural Pathology
IS - 6
ER -