Pituicytoma with gelsolin amyloid deposition

Cristiane M. Ida, Xiaoling Yan, Mark E. Jentoft, N. Sertac Kip, Bernd W. Scheithauer, Jonathan M. Morris, Ahmet Dogan, Joseph E Parisi, Kalman Kovacs

Research output: Contribution to journalArticle

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Abstract

Pituicytoma is a rare low-grade (WHO grade I) sellar region glioma. Among sellar tumors, pituitary adenomas, mainly prolactinomas, may show amyloid deposits. Gelsolin is a ubiquitous calcium-dependent protein that regulates actin filament dynamics. Two known gene point mutations result in gelsolin amyloid deposition, a characteristic feature of a rare type of familial amyloid polyneuropathy (FAP), the Finnish-type FAP, or hereditary gelsolin amyloidosis (HGA). HGA is an autosomal-dominant systemic amyloidosis, characterized by slowly progressive neurological deterioration with corneal lattice dystrophy, cranial neuropathy, and cutis laxa. A unique case of pituicytoma with marked gelsolin amyloid deposition in a 67-year-old Chinese woman is described. MRI revealed a 2.6-cm well-circumscribed, uniformly contrast-enhancing solid sellar mass with suprasellar extension. Histologically, the lesion was characterized by solid sheets and fascicles of spindle cells with slightly fibrillary cytoplasm and oval nuclei with pinpoint nucleoli. Surrounding brain parenchyma showed marked reactive piloid gliosis. Remarkably, conspicuous amyloid deposits were identified as pink homogeneous spherules on light microscopy that showed apple-green birefringence on Congo red with polarization. Mass spectrometric-based proteomic analysis identified the amyloid as gelsolin type. Immunohistochemically, diffuse reactivity to S100 protein and TTF1, focal reactivity for GFAP, and no reactivity to EMA, synaptophysin, and chromogranin were observed. HGA-related mutations were not identified in the tumor. No recurrence was noted 14 months after surgery. To the knowledge of the authors, amyloid deposition in pituicytoma or tumor-associated gelsolin amyloidosis has not been previously described. This novel finding expands the spectrum of sellar tumors that may be associated with amyloid deposition.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalEndocrine Pathology
Volume24
Issue number3
DOIs
StatePublished - Sep 2013

Fingerprint

Gelsolin
Amyloid
Familial Amyloidosis
Familial Amyloid Neuropathies
Amyloid Plaques
Amyloidosis
Neoplasms
Cutis Laxa
Chromogranins
Birefringence
Cranial Nerve Diseases
Prolactinoma
Congo Red
Synaptophysin
Gliosis
S100 Proteins
Pituitary Neoplasms
Actin Cytoskeleton
Point Mutation
Glioma

Keywords

  • Adenoma
  • Amyloid
  • Gelsolin
  • Pituicytoma
  • Pituitary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Ida, C. M., Yan, X., Jentoft, M. E., Kip, N. S., Scheithauer, B. W., Morris, J. M., ... Kovacs, K. (2013). Pituicytoma with gelsolin amyloid deposition. Endocrine Pathology, 24(3), 149-155. https://doi.org/10.1007/s12022-013-9254-y

Pituicytoma with gelsolin amyloid deposition. / Ida, Cristiane M.; Yan, Xiaoling; Jentoft, Mark E.; Kip, N. Sertac; Scheithauer, Bernd W.; Morris, Jonathan M.; Dogan, Ahmet; Parisi, Joseph E; Kovacs, Kalman.

In: Endocrine Pathology, Vol. 24, No. 3, 09.2013, p. 149-155.

Research output: Contribution to journalArticle

Ida, CM, Yan, X, Jentoft, ME, Kip, NS, Scheithauer, BW, Morris, JM, Dogan, A, Parisi, JE & Kovacs, K 2013, 'Pituicytoma with gelsolin amyloid deposition', Endocrine Pathology, vol. 24, no. 3, pp. 149-155. https://doi.org/10.1007/s12022-013-9254-y
Ida CM, Yan X, Jentoft ME, Kip NS, Scheithauer BW, Morris JM et al. Pituicytoma with gelsolin amyloid deposition. Endocrine Pathology. 2013 Sep;24(3):149-155. https://doi.org/10.1007/s12022-013-9254-y
Ida, Cristiane M. ; Yan, Xiaoling ; Jentoft, Mark E. ; Kip, N. Sertac ; Scheithauer, Bernd W. ; Morris, Jonathan M. ; Dogan, Ahmet ; Parisi, Joseph E ; Kovacs, Kalman. / Pituicytoma with gelsolin amyloid deposition. In: Endocrine Pathology. 2013 ; Vol. 24, No. 3. pp. 149-155.
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