Abstract
Background: There is growing interest in white matter (WM) imaging with positron emission tomography (PET). Objectives: We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding. Methods: In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences. Results: MS patients had lower memory (p = 0.03) and language (p = 0.02) performance; smaller thalamic volumes (p = 0.003); and thinner temporal (p = 0.001) and frontal (p = 0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls (p = 0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS (p = 0.0002). Reduced PiB uptake in both the areas of WM hyperintensities (r = 0.65; p = 0.02) and NAWM (r = 0.69; p = 0.01) was associated with decreased visuospatial performance in MS. Conclusion: PiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures’ integrity such as those involved in visuospatial performance.
| Original language | English (US) |
|---|---|
| Journal | Multiple Sclerosis Journal |
| DOIs | |
| State | Accepted/In press - May 1 2017 |
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Keywords
- cognition
- multiple sclerosis
- myelin
- PET
- Pittsburgh compound-B
- thalamus
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis. / Zeydan, Burcu; Lowe, Val; Schwarz, Christopher; Przybelski, Scott A.; Tosakulwong, Nirubol; Zuk, Samantha M.; Senjem, Matthew L.; Gunter, Jeffrey L.; Roberts, Rosebud O; Mielke, Michelle M; Benarroch, Eduardo E.; Rodriguez, Moses; Machulda, Mary Margaret; Lesnick, Timothy G.; Knopman, David S; Petersen, Ronald Carl; Jack, Clifford R Jr.; Kantarci, Kejal M; Kantarci, Orhun H.
In: Multiple Sclerosis Journal, 01.05.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis
AU - Zeydan, Burcu
AU - Lowe, Val
AU - Schwarz, Christopher
AU - Przybelski, Scott A.
AU - Tosakulwong, Nirubol
AU - Zuk, Samantha M.
AU - Senjem, Matthew L.
AU - Gunter, Jeffrey L.
AU - Roberts, Rosebud O
AU - Mielke, Michelle M
AU - Benarroch, Eduardo E.
AU - Rodriguez, Moses
AU - Machulda, Mary Margaret
AU - Lesnick, Timothy G.
AU - Knopman, David S
AU - Petersen, Ronald Carl
AU - Jack, Clifford R Jr.
AU - Kantarci, Kejal M
AU - Kantarci, Orhun H
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Background: There is growing interest in white matter (WM) imaging with positron emission tomography (PET). Objectives: We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding. Methods: In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences. Results: MS patients had lower memory (p = 0.03) and language (p = 0.02) performance; smaller thalamic volumes (p = 0.003); and thinner temporal (p = 0.001) and frontal (p = 0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls (p = 0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS (p = 0.0002). Reduced PiB uptake in both the areas of WM hyperintensities (r = 0.65; p = 0.02) and NAWM (r = 0.69; p = 0.01) was associated with decreased visuospatial performance in MS. Conclusion: PiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures’ integrity such as those involved in visuospatial performance.
AB - Background: There is growing interest in white matter (WM) imaging with positron emission tomography (PET). Objectives: We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding. Methods: In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences. Results: MS patients had lower memory (p = 0.03) and language (p = 0.02) performance; smaller thalamic volumes (p = 0.003); and thinner temporal (p = 0.001) and frontal (p = 0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls (p = 0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS (p = 0.0002). Reduced PiB uptake in both the areas of WM hyperintensities (r = 0.65; p = 0.02) and NAWM (r = 0.69; p = 0.01) was associated with decreased visuospatial performance in MS. Conclusion: PiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures’ integrity such as those involved in visuospatial performance.
KW - cognition
KW - multiple sclerosis
KW - myelin
KW - PET
KW - Pittsburgh compound-B
KW - thalamus
UR - http://www.scopus.com/inward/record.url?scp=85043307235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043307235&partnerID=8YFLogxK
U2 - 10.1177/1352458517707346
DO - 10.1177/1352458517707346
M3 - Article
AN - SCOPUS:85043307235
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
ER -