Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy

Kazuki Sumiyama, Christopher J. Gostout, Elizabeth Rajan, Timothy A. Bakken, Jodie L. Deters, Mary A. Knipschield, Robert H. Hawes, Anthony N. Kalloo, Pankaj J. Pasricha, Sydney Chung, Sergey V. Kantsevoy, Peter B. Cotton

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background: Iatrogenic inflammation of the porcine uterine horn may serve as an in vivo appendicitis model for the development of endoscopic transgastric appendectomy. Objective: Five female pigs. Study Design: Animal study. Settings: General anesthesia. Main Outcome Measurements: Anatomical appearance and technical feasibility. Interventions: Three pigs were used to identify an injectable material that would inflame the uterine horn, and 2 pigs were used for a pilot appendectomy. Three types of materials were individually injected into the bilateral uterine horns, and the ideal material to inflame the uterine horn was injected into the right uterine horn for the last 2 pigs. After 24 hours, the injected uterine horns of the first 3 pigs were assessed and a pilot appendectomy was performed in the last 2 pigs. Results: Ethanolamine oleate (EO) injected uterine horns demonstrated similarities to the inflamed human appendix. Simulations of the appendectomy were successfully performed by using the EO model. Limitations: Suboptimal existing tools. Conclusions: This preliminary study demonstrated the technical feasibility to create a model for acute appendicitis by using the porcine uterine horn and transgastric appendectomy.

Original languageEnglish (US)
Pages (from-to)808-812
Number of pages5
JournalGastrointestinal Endoscopy
Volume64
Issue number5
DOIs
StatePublished - Nov 2006

Fingerprint

Appendectomy
Appendicitis
Swine
General Anesthesia
Inflammation
Injections

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sumiyama, K., Gostout, C. J., Rajan, E., Bakken, T. A., Deters, J. L., Knipschield, M. A., ... Cotton, P. B. (2006). Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy. Gastrointestinal Endoscopy, 64(5), 808-812. https://doi.org/10.1016/j.gie.2006.04.038

Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy. / Sumiyama, Kazuki; Gostout, Christopher J.; Rajan, Elizabeth; Bakken, Timothy A.; Deters, Jodie L.; Knipschield, Mary A.; Hawes, Robert H.; Kalloo, Anthony N.; Pasricha, Pankaj J.; Chung, Sydney; Kantsevoy, Sergey V.; Cotton, Peter B.

In: Gastrointestinal Endoscopy, Vol. 64, No. 5, 11.2006, p. 808-812.

Research output: Contribution to journalArticle

Sumiyama, K, Gostout, CJ, Rajan, E, Bakken, TA, Deters, JL, Knipschield, MA, Hawes, RH, Kalloo, AN, Pasricha, PJ, Chung, S, Kantsevoy, SV & Cotton, PB 2006, 'Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy', Gastrointestinal Endoscopy, vol. 64, no. 5, pp. 808-812. https://doi.org/10.1016/j.gie.2006.04.038
Sumiyama, Kazuki ; Gostout, Christopher J. ; Rajan, Elizabeth ; Bakken, Timothy A. ; Deters, Jodie L. ; Knipschield, Mary A. ; Hawes, Robert H. ; Kalloo, Anthony N. ; Pasricha, Pankaj J. ; Chung, Sydney ; Kantsevoy, Sergey V. ; Cotton, Peter B. / Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy. In: Gastrointestinal Endoscopy. 2006 ; Vol. 64, No. 5. pp. 808-812.
@article{5b56ac6b0c8245e39c6b432ee2cfef42,
title = "Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy",
abstract = "Background: Iatrogenic inflammation of the porcine uterine horn may serve as an in vivo appendicitis model for the development of endoscopic transgastric appendectomy. Objective: Five female pigs. Study Design: Animal study. Settings: General anesthesia. Main Outcome Measurements: Anatomical appearance and technical feasibility. Interventions: Three pigs were used to identify an injectable material that would inflame the uterine horn, and 2 pigs were used for a pilot appendectomy. Three types of materials were individually injected into the bilateral uterine horns, and the ideal material to inflame the uterine horn was injected into the right uterine horn for the last 2 pigs. After 24 hours, the injected uterine horns of the first 3 pigs were assessed and a pilot appendectomy was performed in the last 2 pigs. Results: Ethanolamine oleate (EO) injected uterine horns demonstrated similarities to the inflamed human appendix. Simulations of the appendectomy were successfully performed by using the EO model. Limitations: Suboptimal existing tools. Conclusions: This preliminary study demonstrated the technical feasibility to create a model for acute appendicitis by using the porcine uterine horn and transgastric appendectomy.",
author = "Kazuki Sumiyama and Gostout, {Christopher J.} and Elizabeth Rajan and Bakken, {Timothy A.} and Deters, {Jodie L.} and Knipschield, {Mary A.} and Hawes, {Robert H.} and Kalloo, {Anthony N.} and Pasricha, {Pankaj J.} and Sydney Chung and Kantsevoy, {Sergey V.} and Cotton, {Peter B.}",
year = "2006",
month = "11",
doi = "10.1016/j.gie.2006.04.038",
language = "English (US)",
volume = "64",
pages = "808--812",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy

AU - Sumiyama, Kazuki

AU - Gostout, Christopher J.

AU - Rajan, Elizabeth

AU - Bakken, Timothy A.

AU - Deters, Jodie L.

AU - Knipschield, Mary A.

AU - Hawes, Robert H.

AU - Kalloo, Anthony N.

AU - Pasricha, Pankaj J.

AU - Chung, Sydney

AU - Kantsevoy, Sergey V.

AU - Cotton, Peter B.

PY - 2006/11

Y1 - 2006/11

N2 - Background: Iatrogenic inflammation of the porcine uterine horn may serve as an in vivo appendicitis model for the development of endoscopic transgastric appendectomy. Objective: Five female pigs. Study Design: Animal study. Settings: General anesthesia. Main Outcome Measurements: Anatomical appearance and technical feasibility. Interventions: Three pigs were used to identify an injectable material that would inflame the uterine horn, and 2 pigs were used for a pilot appendectomy. Three types of materials were individually injected into the bilateral uterine horns, and the ideal material to inflame the uterine horn was injected into the right uterine horn for the last 2 pigs. After 24 hours, the injected uterine horns of the first 3 pigs were assessed and a pilot appendectomy was performed in the last 2 pigs. Results: Ethanolamine oleate (EO) injected uterine horns demonstrated similarities to the inflamed human appendix. Simulations of the appendectomy were successfully performed by using the EO model. Limitations: Suboptimal existing tools. Conclusions: This preliminary study demonstrated the technical feasibility to create a model for acute appendicitis by using the porcine uterine horn and transgastric appendectomy.

AB - Background: Iatrogenic inflammation of the porcine uterine horn may serve as an in vivo appendicitis model for the development of endoscopic transgastric appendectomy. Objective: Five female pigs. Study Design: Animal study. Settings: General anesthesia. Main Outcome Measurements: Anatomical appearance and technical feasibility. Interventions: Three pigs were used to identify an injectable material that would inflame the uterine horn, and 2 pigs were used for a pilot appendectomy. Three types of materials were individually injected into the bilateral uterine horns, and the ideal material to inflame the uterine horn was injected into the right uterine horn for the last 2 pigs. After 24 hours, the injected uterine horns of the first 3 pigs were assessed and a pilot appendectomy was performed in the last 2 pigs. Results: Ethanolamine oleate (EO) injected uterine horns demonstrated similarities to the inflamed human appendix. Simulations of the appendectomy were successfully performed by using the EO model. Limitations: Suboptimal existing tools. Conclusions: This preliminary study demonstrated the technical feasibility to create a model for acute appendicitis by using the porcine uterine horn and transgastric appendectomy.

UR - http://www.scopus.com/inward/record.url?scp=33749989810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749989810&partnerID=8YFLogxK

U2 - 10.1016/j.gie.2006.04.038

DO - 10.1016/j.gie.2006.04.038

M3 - Article

C2 - 17055881

AN - SCOPUS:33749989810

VL - 64

SP - 808

EP - 812

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 5

ER -