Abstract
We aimed to compare gastrointestinal transit and defecatory function in a random sample of people with or without diabetes mellitus in a US community who reported constipation or laxative use. In this pilot study we measured: gastric, small bowel, and colonic transit by scintigraphy; vector manometry of anal sphincters at rest and during squeeze; defecatory dynamics by balloon expulsion test; and scintigraphic measurement of anorectal angle at rest and during defecation. Autonomic function tests were performed in diabetics. Diabetics with constipation had a higher prevalence of abnormal evacuation or prolonged colonic transit during the first 24 hr than controls (P = 0.07): three had prolonged 24-hr colonic transit, and three abnormal evacuation. Among constipated controls, only one had anismus. Overall, diabetics had slower colonic transit during the first 24 hr than nondiabetics (P < 0.05). Community diabetics who experience constipation or use laxatives have a greater prevalence of delayed 24-hr colonic transit or evacuatory dysfunction than community controls.
Original language | English (US) |
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Pages (from-to) | 2373-2378 |
Number of pages | 6 |
Journal | Digestive diseases and sciences |
Volume | 43 |
Issue number | 11 |
DOIs | |
State | Published - 1998 |
Keywords
- Colonic transit anismus
- Community
- Diabetes mellitus
- Evacuation disorder
ASJC Scopus subject areas
- Physiology
- Gastroenterology