Pilot study of detection, radiologist confidence and image quality with sinogram-affirmed iterative reconstruction at half-routine dose level

Joel G. Fletcher, William R. Krueger, David M. Hough, James E. Huprich, Jeff L. Fidler, Jia Wang, Maria M. Shiung, W. Scott Harmsen, Katharine L. Grant, Cynthia H. McCollough

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

OBJECTIVE: The objective of this study was to determine the effect of Sinogram-Affirmed Iterative Reconstruction (SAFIRE) on radiological detection, diagnostic confidence, and image quality at half-dose, contrast-enhanced abdominopelvic computed tomography. METHODS: Forty dual-source examinations were reconstructed using routine-dose with filtered back projection, half-dose filtered back projection, and half-dose SAFIRE. Three radiologists detected lesions in abdominopelvic organs, reporting findings of potential medical significance, diagnostic confidence, and image quality. RESULTS: There was greater than 78% concordance between full- and half-dose images ± SAFIRE, and no difference in the detection of lesions within organs between half-dose images ± SAFIRE (P = 0.22 - 1.0). Detection of potentially important findings varied by reader, but not between dose/reconstruction methods. Diagnostic confidence varied widely (P < 0.001 to P > 0.91). Sinogram-Affirmed Iterative Reconstruction significantly improved image quality in the pelvis (P ≤ 0.04). CONCLUSIONS: Half-dose images ± SAFIRE had organ-specific detections similar to routine-dose images. Sinogram-Affirmed Iterative Reconstruction improved image quality in the pelvis, but diagnostic confidence and image quality scores in the abdomen depended on the reader.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalJournal of computer assisted tomography
Volume37
Issue number2
DOIs
StatePublished - Mar 1 2013

Keywords

  • CT
  • Image enhancement
  • Observer variation
  • Radiation dosage

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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