TY - JOUR
T1 - Pilot Study Comparing 2 Oral Rehydration Solutions in Patients With Short Bowel Syndrome Receiving Home Parenteral Nutrition
T2 - A Prospective Double-Blind Randomized Controlled Trial
AU - Hurt, Ryan T.
AU - Vallumsetla, Nishanth
AU - Edakkanambeth Varayil, Jithinraj
AU - Bonnes, Sara L.
AU - Nanda, Sanjeev
AU - Nadeau, Joseph
AU - Mundi, Manpreet S.
N1 - Funding Information:
Financial disclosure: DripDrop, Inc (Oakland, California) provided the DripDrop solution used in the study. Other study costs were covered by a small grant award from the Mayo Clinic, Division of General Internal Medicine (Rochester, Minnesota).
Publisher Copyright:
© 2017, © 2017 American Society for Parenteral and Enteral Nutrition.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background: Short bowel syndrome (SBS) is a common indication for home parenteral nutrition (HPN). Oral rehydration solutions (ORSs) have the ability to supplement or reduce HPN dependence. However, ORSs have suffered from poor taste profiles, making long-term consumption and compliance unlikely. The goal of the current study was to assess the taste and compliance of 2 ORSs among patients with SBS requiring HPN. Methods: All participants with SBS receiving HPN with anticipated duration >3 months were offered enrollment: 31 participants met inclusion criteria; 3 declined enrollment; and 28 were randomized to receive a modified World Health Organization ORS (group A) or a commercially available ORS (DripDrop; group B). Results: Six participants dropped out shortly after randomization (3 in each group) due to poor taste or intolerance. An additional 3 (1 in group A and 2 in group B) discontinued the ORS before the end of the study at 6 months. At the end of the study, 19 remained. The mean taste rating given by the participants was, on a scale of 1–10, 7.3 ± 1.9 for group A and 7.6 ± 1.6 for group B (P =.61). The mean number of days that ORSs were consumed each week was 6.0 ± 1.3 for group A and 6.6 ± 1 days for group B (P =.06). Conclusion: Taste rating was not different for both ORSs; however, a significant number of participants did not complete the study.
AB - Background: Short bowel syndrome (SBS) is a common indication for home parenteral nutrition (HPN). Oral rehydration solutions (ORSs) have the ability to supplement or reduce HPN dependence. However, ORSs have suffered from poor taste profiles, making long-term consumption and compliance unlikely. The goal of the current study was to assess the taste and compliance of 2 ORSs among patients with SBS requiring HPN. Methods: All participants with SBS receiving HPN with anticipated duration >3 months were offered enrollment: 31 participants met inclusion criteria; 3 declined enrollment; and 28 were randomized to receive a modified World Health Organization ORS (group A) or a commercially available ORS (DripDrop; group B). Results: Six participants dropped out shortly after randomization (3 in each group) due to poor taste or intolerance. An additional 3 (1 in group A and 2 in group B) discontinued the ORS before the end of the study at 6 months. At the end of the study, 19 remained. The mean taste rating given by the participants was, on a scale of 1–10, 7.3 ± 1.9 for group A and 7.6 ± 1.6 for group B (P =.61). The mean number of days that ORSs were consumed each week was 6.0 ± 1.3 for group A and 6.6 ± 1 days for group B (P =.06). Conclusion: Taste rating was not different for both ORSs; however, a significant number of participants did not complete the study.
KW - dehydration
KW - fluid therapy
KW - parenteral nutrition
KW - rehydration solutions
KW - short bowel syndrome
KW - water-electrolyte balance
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U2 - 10.1177/0884533617714975
DO - 10.1177/0884533617714975
M3 - Article
C2 - 28662613
AN - SCOPUS:85034429526
SN - 0884-5336
VL - 32
SP - 814
EP - 819
JO - Nutrition in Clinical Practice
JF - Nutrition in Clinical Practice
IS - 6
ER -