Pilot Study Comparing 2 Oral Rehydration Solutions in Patients With Short Bowel Syndrome Receiving Home Parenteral Nutrition: A Prospective Double-Blind Randomized Controlled Trial

Ryan T Hurt, Nishanth Vallumsetla, Jithinraj Edakkanambeth Varayil, Sara L. Bonnes, Sanjeev Nanda, Joseph Nadeau, Manpreet S. Mundi

Research output: Contribution to journalArticle

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Background: Short bowel syndrome (SBS) is a common indication for home parenteral nutrition (HPN). Oral rehydration solutions (ORSs) have the ability to supplement or reduce HPN dependence. However, ORSs have suffered from poor taste profiles, making long-term consumption and compliance unlikely. The goal of the current study was to assess the taste and compliance of 2 ORSs among patients with SBS requiring HPN. Methods: All participants with SBS receiving HPN with anticipated duration >3 months were offered enrollment: 31 participants met inclusion criteria; 3 declined enrollment; and 28 were randomized to receive a modified World Health Organization ORS (group A) or a commercially available ORS (DripDrop; group B). Results: Six participants dropped out shortly after randomization (3 in each group) due to poor taste or intolerance. An additional 3 (1 in group A and 2 in group B) discontinued the ORS before the end of the study at 6 months. At the end of the study, 19 remained. The mean taste rating given by the participants was, on a scale of 1–10, 7.3 ± 1.9 for group A and 7.6 ± 1.6 for group B (P =.61). The mean number of days that ORSs were consumed each week was 6.0 ± 1.3 for group A and 6.6 ± 1 days for group B (P =.06). Conclusion: Taste rating was not different for both ORSs; however, a significant number of participants did not complete the study.

Original languageEnglish (US)
Pages (from-to)814-819
Number of pages6
JournalNutrition in Clinical Practice
Issue number6
StatePublished - Dec 1 2017



  • dehydration
  • fluid therapy
  • parenteral nutrition
  • rehydration solutions
  • short bowel syndrome
  • water-electrolyte balance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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