Pilot multi-reader study demonstrating potential for dose reduction in dual energy hepatic CT using non-linear blending of mixed kV image datasets

Anja Apel, Joel Garland Fletcher, Jeff L. Fidler, David M. Hough, Lifeng Yu, Luis S. Guimaraes, Matthias E. Bellemann, Cynthia H McCollough, David R. Holmes III, Christian D. Eusemann

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: To determine the potential for radiation dose reduction using sigmoidally-blended mixed-kV images from dual energy (DE) hepatic CT. Methods: Multiple contrast-enhanced, DE (80 kV/140 kV) datasets were reconstructed from 34 patients undergoing clinically-indicated examinations using routine CTDI vol. Noise was inserted in projection-space to simulate six dose levels reflecting 25-100% of the original dose. Three radiologists, blinded to dose, evaluated image preference, image quality, and diagnostic confidence (scale 1 to 5) using sigmoidally-blended, mixed-kV images, identifying the lowest acceptable dose (both image quality and confidence scores ≥4). At this lowest acceptable dose, the sigmoidal, 0.5 and 0.3 linear blended images were ranked in order of preference. Results: Radiation dose level correlated with image preference (correlation coefficients = 0.94, 0.81, 0.94). However, 82% (28/34) and 97% (33/34) of examinations corresponding to dose reductions of 45% and 30%, respectively, yielded acceptable image quality and confidence for all three radiologists. These frequencies were similar whether or not a lesion was present. Each radiologist had specific preferences between mixed-kV image display techniques (p≤0.006), with two most often preferring sigmoidally-blended images. Conclusions: There is potential for further dose reduction utilizing DE hepatic CT. Radiologist visual preference for mixed-kV images is idiosyncratic.

Original languageEnglish (US)
Pages (from-to)644-652
Number of pages9
JournalEuropean Radiology
Volume21
Issue number3
DOIs
StatePublished - 2011

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Liver
Radiation
Noise
Radiologists
Datasets

Keywords

  • Dual energy scanned projection
  • Liver
  • Radiation dosage
  • Radiography
  • Subtraction technique
  • Tomography
  • X-ray computed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Pilot multi-reader study demonstrating potential for dose reduction in dual energy hepatic CT using non-linear blending of mixed kV image datasets. / Apel, Anja; Fletcher, Joel Garland; Fidler, Jeff L.; Hough, David M.; Yu, Lifeng; Guimaraes, Luis S.; Bellemann, Matthias E.; McCollough, Cynthia H; Holmes III, David R.; Eusemann, Christian D.

In: European Radiology, Vol. 21, No. 3, 2011, p. 644-652.

Research output: Contribution to journalArticle

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title = "Pilot multi-reader study demonstrating potential for dose reduction in dual energy hepatic CT using non-linear blending of mixed kV image datasets",
abstract = "Objective: To determine the potential for radiation dose reduction using sigmoidally-blended mixed-kV images from dual energy (DE) hepatic CT. Methods: Multiple contrast-enhanced, DE (80 kV/140 kV) datasets were reconstructed from 34 patients undergoing clinically-indicated examinations using routine CTDI vol. Noise was inserted in projection-space to simulate six dose levels reflecting 25-100{\%} of the original dose. Three radiologists, blinded to dose, evaluated image preference, image quality, and diagnostic confidence (scale 1 to 5) using sigmoidally-blended, mixed-kV images, identifying the lowest acceptable dose (both image quality and confidence scores ≥4). At this lowest acceptable dose, the sigmoidal, 0.5 and 0.3 linear blended images were ranked in order of preference. Results: Radiation dose level correlated with image preference (correlation coefficients = 0.94, 0.81, 0.94). However, 82{\%} (28/34) and 97{\%} (33/34) of examinations corresponding to dose reductions of 45{\%} and 30{\%}, respectively, yielded acceptable image quality and confidence for all three radiologists. These frequencies were similar whether or not a lesion was present. Each radiologist had specific preferences between mixed-kV image display techniques (p≤0.006), with two most often preferring sigmoidally-blended images. Conclusions: There is potential for further dose reduction utilizing DE hepatic CT. Radiologist visual preference for mixed-kV images is idiosyncratic.",
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AU - Apel, Anja

AU - Fletcher, Joel Garland

AU - Fidler, Jeff L.

AU - Hough, David M.

AU - Yu, Lifeng

AU - Guimaraes, Luis S.

AU - Bellemann, Matthias E.

AU - McCollough, Cynthia H

AU - Holmes III, David R.

AU - Eusemann, Christian D.

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N2 - Objective: To determine the potential for radiation dose reduction using sigmoidally-blended mixed-kV images from dual energy (DE) hepatic CT. Methods: Multiple contrast-enhanced, DE (80 kV/140 kV) datasets were reconstructed from 34 patients undergoing clinically-indicated examinations using routine CTDI vol. Noise was inserted in projection-space to simulate six dose levels reflecting 25-100% of the original dose. Three radiologists, blinded to dose, evaluated image preference, image quality, and diagnostic confidence (scale 1 to 5) using sigmoidally-blended, mixed-kV images, identifying the lowest acceptable dose (both image quality and confidence scores ≥4). At this lowest acceptable dose, the sigmoidal, 0.5 and 0.3 linear blended images were ranked in order of preference. Results: Radiation dose level correlated with image preference (correlation coefficients = 0.94, 0.81, 0.94). However, 82% (28/34) and 97% (33/34) of examinations corresponding to dose reductions of 45% and 30%, respectively, yielded acceptable image quality and confidence for all three radiologists. These frequencies were similar whether or not a lesion was present. Each radiologist had specific preferences between mixed-kV image display techniques (p≤0.006), with two most often preferring sigmoidally-blended images. Conclusions: There is potential for further dose reduction utilizing DE hepatic CT. Radiologist visual preference for mixed-kV images is idiosyncratic.

AB - Objective: To determine the potential for radiation dose reduction using sigmoidally-blended mixed-kV images from dual energy (DE) hepatic CT. Methods: Multiple contrast-enhanced, DE (80 kV/140 kV) datasets were reconstructed from 34 patients undergoing clinically-indicated examinations using routine CTDI vol. Noise was inserted in projection-space to simulate six dose levels reflecting 25-100% of the original dose. Three radiologists, blinded to dose, evaluated image preference, image quality, and diagnostic confidence (scale 1 to 5) using sigmoidally-blended, mixed-kV images, identifying the lowest acceptable dose (both image quality and confidence scores ≥4). At this lowest acceptable dose, the sigmoidal, 0.5 and 0.3 linear blended images were ranked in order of preference. Results: Radiation dose level correlated with image preference (correlation coefficients = 0.94, 0.81, 0.94). However, 82% (28/34) and 97% (33/34) of examinations corresponding to dose reductions of 45% and 30%, respectively, yielded acceptable image quality and confidence for all three radiologists. These frequencies were similar whether or not a lesion was present. Each radiologist had specific preferences between mixed-kV image display techniques (p≤0.006), with two most often preferring sigmoidally-blended images. Conclusions: There is potential for further dose reduction utilizing DE hepatic CT. Radiologist visual preference for mixed-kV images is idiosyncratic.

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KW - Radiography

KW - Subtraction technique

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KW - X-ray computed

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