Pilot comparison of 18F-fluorocholine and 18F- fluorodeoxyglucose PET/CT with conventional imaging in prostate cancer

J. M. Beauregard, S. G. Williams, Timothy R DeGrado, P. Roselt, R. J. Hicks

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Introduction: Conventional imaging (CI) is known to have limitations with respect to staging of patients with primary or relapsed prostate cancer. Positron emission tomography/computed tomography (PET/CT) with 18F-flurodeoxyglucose (FDG) is also often suboptimal because of low tracer avidity, but 18F-fluorocholine (FCH) appears to be a promising alternative molecular imaging probe. We report a prospective pilot study of PET/CT comparing both tracers for staging and restaging of patients with prostate cancer. Methods: Sixteen prostate cancer patients were evaluated (7 for staging and 9 for restaging). All patients also underwent CI, comprising at least an abdominopelvic CT and a bone scan. All imaging results and other relevant data were extracted from the imaging reports and medical charts. Results: Based on all imaging-detected disease sites, both FCH-PET/CT and FDG-PET/CT (79%) were more sensitive than CI (14%), with the highest number of sites of nodal and distant disease on FCH PET/CT. FCH-PET/CT alone would have provided sufficient clinical information to form an appropriate management plan in 88% of cases, as compared with 56% for CI. Conclusion: FCH-PET/CT has the potential to impact on the management of patients with prostate cancer significantly more often than CI.

Original languageEnglish (US)
Pages (from-to)325-332
Number of pages8
JournalJournal of Medical Imaging and Radiation Oncology
Volume54
Issue number4
DOIs
StatePublished - Aug 2010
Externally publishedYes

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Keywords

  • F-Fluorocholine
  • F-Fluorodeoxyglucose
  • cancer staging
  • positron emission tomography
  • prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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