Pilocytic astrocytomas: Well-demarcated magnetic resonance appearance despite frequent infiltration histologically

K. J. Coakley, John III Huston, B. W. Scheithauer, G. Forbes, P. J. Kelly

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objective: To determine the magnetic resonance imaging (MRI) characteristics of pilocytic astrocytomas and to correlate them with the histopathologic findings. Material and Methods: MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MRI were compared with those on computed tomography. Results: The tumors occurred at all levels of the central nervous system, including the spinal cord. The intracranial tumors were periventricular (73%) or periaqueductal (9%). All tumors were typical pilocytic astrocytomas and were grade 1 on the basis of the World Health Organization classification. At operation, they were often circumscribed and cystic. Radiologically, the tumors were well demarcated (96%), had benign morphologic features, and almost always showed enhancement (94%). Conclusion: MRI of pilocytic astrocytomas typically demonstrated a relatively large, sharply demarcated periventricular mass with pronounced contrast enhancement but minimal or no associated edema. Often, the tumors were cystic on MRI. Despite the well-demarcated appearance grossly and on MRI, pathologic review showed that many of these tumors (64%) infiltrated the surrounding parenchyma, particularly the white matter.

Original languageEnglish (US)
Pages (from-to)747-751
Number of pages5
JournalMayo Clinic Proceedings
Volume70
Issue number8
StatePublished - 1995

Fingerprint

Astrocytoma
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Neoplasms
Edema
Spinal Cord
Central Nervous System
Tomography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pilocytic astrocytomas : Well-demarcated magnetic resonance appearance despite frequent infiltration histologically. / Coakley, K. J.; Huston, John III; Scheithauer, B. W.; Forbes, G.; Kelly, P. J.

In: Mayo Clinic Proceedings, Vol. 70, No. 8, 1995, p. 747-751.

Research output: Contribution to journalArticle

Coakley, K. J. ; Huston, John III ; Scheithauer, B. W. ; Forbes, G. ; Kelly, P. J. / Pilocytic astrocytomas : Well-demarcated magnetic resonance appearance despite frequent infiltration histologically. In: Mayo Clinic Proceedings. 1995 ; Vol. 70, No. 8. pp. 747-751.
@article{da1a776c988e4da1aad4472fefd8bff9,
title = "Pilocytic astrocytomas: Well-demarcated magnetic resonance appearance despite frequent infiltration histologically",
abstract = "Objective: To determine the magnetic resonance imaging (MRI) characteristics of pilocytic astrocytomas and to correlate them with the histopathologic findings. Material and Methods: MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MRI were compared with those on computed tomography. Results: The tumors occurred at all levels of the central nervous system, including the spinal cord. The intracranial tumors were periventricular (73{\%}) or periaqueductal (9{\%}). All tumors were typical pilocytic astrocytomas and were grade 1 on the basis of the World Health Organization classification. At operation, they were often circumscribed and cystic. Radiologically, the tumors were well demarcated (96{\%}), had benign morphologic features, and almost always showed enhancement (94{\%}). Conclusion: MRI of pilocytic astrocytomas typically demonstrated a relatively large, sharply demarcated periventricular mass with pronounced contrast enhancement but minimal or no associated edema. Often, the tumors were cystic on MRI. Despite the well-demarcated appearance grossly and on MRI, pathologic review showed that many of these tumors (64{\%}) infiltrated the surrounding parenchyma, particularly the white matter.",
author = "Coakley, {K. J.} and Huston, {John III} and Scheithauer, {B. W.} and G. Forbes and Kelly, {P. J.}",
year = "1995",
language = "English (US)",
volume = "70",
pages = "747--751",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "8",

}

TY - JOUR

T1 - Pilocytic astrocytomas

T2 - Well-demarcated magnetic resonance appearance despite frequent infiltration histologically

AU - Coakley, K. J.

AU - Huston, John III

AU - Scheithauer, B. W.

AU - Forbes, G.

AU - Kelly, P. J.

PY - 1995

Y1 - 1995

N2 - Objective: To determine the magnetic resonance imaging (MRI) characteristics of pilocytic astrocytomas and to correlate them with the histopathologic findings. Material and Methods: MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MRI were compared with those on computed tomography. Results: The tumors occurred at all levels of the central nervous system, including the spinal cord. The intracranial tumors were periventricular (73%) or periaqueductal (9%). All tumors were typical pilocytic astrocytomas and were grade 1 on the basis of the World Health Organization classification. At operation, they were often circumscribed and cystic. Radiologically, the tumors were well demarcated (96%), had benign morphologic features, and almost always showed enhancement (94%). Conclusion: MRI of pilocytic astrocytomas typically demonstrated a relatively large, sharply demarcated periventricular mass with pronounced contrast enhancement but minimal or no associated edema. Often, the tumors were cystic on MRI. Despite the well-demarcated appearance grossly and on MRI, pathologic review showed that many of these tumors (64%) infiltrated the surrounding parenchyma, particularly the white matter.

AB - Objective: To determine the magnetic resonance imaging (MRI) characteristics of pilocytic astrocytomas and to correlate them with the histopathologic findings. Material and Methods: MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MRI were compared with those on computed tomography. Results: The tumors occurred at all levels of the central nervous system, including the spinal cord. The intracranial tumors were periventricular (73%) or periaqueductal (9%). All tumors were typical pilocytic astrocytomas and were grade 1 on the basis of the World Health Organization classification. At operation, they were often circumscribed and cystic. Radiologically, the tumors were well demarcated (96%), had benign morphologic features, and almost always showed enhancement (94%). Conclusion: MRI of pilocytic astrocytomas typically demonstrated a relatively large, sharply demarcated periventricular mass with pronounced contrast enhancement but minimal or no associated edema. Often, the tumors were cystic on MRI. Despite the well-demarcated appearance grossly and on MRI, pathologic review showed that many of these tumors (64%) infiltrated the surrounding parenchyma, particularly the white matter.

UR - http://www.scopus.com/inward/record.url?scp=0029144874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029144874&partnerID=8YFLogxK

M3 - Article

C2 - 7630212

AN - SCOPUS:0029144874

VL - 70

SP - 747

EP - 751

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 8

ER -