Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease

Dennis W Dickson, S. H. Yen, D. S. Horoupian

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Pick body-like inclusions are described in the granular neurons of the dentate fascia in Alzheimer's disease. The inclusions are round, argyrophilic and stained by thioflavine-S. Immunocytochemically they contain antigenic determinants of neurofilaments and of Alzheimer neurofibrillary tangles. Ultrastructurally they are composed primarily of 15-18 nm straight filaments similar to the neurofibrillary pathology of progressive supranuclear palsy and Pick's disease. The dentate fascia inclusions, as well as cerebellar plaques but not amyloid angiopathy, are found most frequently in association with severe neurofibrillary degeneration.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalActa Neuropathologica
Volume71
Issue number1-2
DOIs
StatePublished - Mar 1986
Externally publishedYes

Fingerprint

Inclusion Bodies
Dentate Gyrus
Hippocampus
Alzheimer Disease
Pick Disease of the Brain
Progressive Supranuclear Palsy
Neurofibrillary Tangles
Intermediate Filaments
Epitopes
Pathology
Neurons
Amyloid angiopathy
thioflavin T

Keywords

  • Alzheimer's disease
  • Immunocytochemistry
  • Neurofibrillary degeneration
  • Pick bodies
  • Thioflavine-S

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease. / Dickson, Dennis W; Yen, S. H.; Horoupian, D. S.

In: Acta Neuropathologica, Vol. 71, No. 1-2, 03.1986, p. 38-45.

Research output: Contribution to journalArticle

@article{44617586c710493f8d5a78c82255cc95,
title = "Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease",
abstract = "Pick body-like inclusions are described in the granular neurons of the dentate fascia in Alzheimer's disease. The inclusions are round, argyrophilic and stained by thioflavine-S. Immunocytochemically they contain antigenic determinants of neurofilaments and of Alzheimer neurofibrillary tangles. Ultrastructurally they are composed primarily of 15-18 nm straight filaments similar to the neurofibrillary pathology of progressive supranuclear palsy and Pick's disease. The dentate fascia inclusions, as well as cerebellar plaques but not amyloid angiopathy, are found most frequently in association with severe neurofibrillary degeneration.",
keywords = "Alzheimer's disease, Immunocytochemistry, Neurofibrillary degeneration, Pick bodies, Thioflavine-S",
author = "Dickson, {Dennis W} and Yen, {S. H.} and Horoupian, {D. S.}",
year = "1986",
month = "3",
doi = "10.1007/BF00687960",
language = "English (US)",
volume = "71",
pages = "38--45",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "1-2",

}

TY - JOUR

T1 - Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease

AU - Dickson, Dennis W

AU - Yen, S. H.

AU - Horoupian, D. S.

PY - 1986/3

Y1 - 1986/3

N2 - Pick body-like inclusions are described in the granular neurons of the dentate fascia in Alzheimer's disease. The inclusions are round, argyrophilic and stained by thioflavine-S. Immunocytochemically they contain antigenic determinants of neurofilaments and of Alzheimer neurofibrillary tangles. Ultrastructurally they are composed primarily of 15-18 nm straight filaments similar to the neurofibrillary pathology of progressive supranuclear palsy and Pick's disease. The dentate fascia inclusions, as well as cerebellar plaques but not amyloid angiopathy, are found most frequently in association with severe neurofibrillary degeneration.

AB - Pick body-like inclusions are described in the granular neurons of the dentate fascia in Alzheimer's disease. The inclusions are round, argyrophilic and stained by thioflavine-S. Immunocytochemically they contain antigenic determinants of neurofilaments and of Alzheimer neurofibrillary tangles. Ultrastructurally they are composed primarily of 15-18 nm straight filaments similar to the neurofibrillary pathology of progressive supranuclear palsy and Pick's disease. The dentate fascia inclusions, as well as cerebellar plaques but not amyloid angiopathy, are found most frequently in association with severe neurofibrillary degeneration.

KW - Alzheimer's disease

KW - Immunocytochemistry

KW - Neurofibrillary degeneration

KW - Pick bodies

KW - Thioflavine-S

UR - http://www.scopus.com/inward/record.url?scp=0022512318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022512318&partnerID=8YFLogxK

U2 - 10.1007/BF00687960

DO - 10.1007/BF00687960

M3 - Article

C2 - 3022536

AN - SCOPUS:0022512318

VL - 71

SP - 38

EP - 45

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 1-2

ER -