Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease

D. W. Dickson, S. H. Yen, D. S. Horoupian

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Pick body-like inclusions are described in the granular neurons of the dentate fascia in Alzheimer's disease. The inclusions are round, argyrophilic and stained by thioflavine-S. Immunocytochemically they contain antigenic determinants of neurofilaments and of Alzheimer neurofibrillary tangles. Ultrastructurally they are composed primarily of 15-18 nm straight filaments similar to the neurofibrillary pathology of progressive supranuclear palsy and Pick's disease. The dentate fascia inclusions, as well as cerebellar plaques but not amyloid angiopathy, are found most frequently in association with severe neurofibrillary degeneration.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalActa neuropathologica
Volume71
Issue number1-2
DOIs
StatePublished - Mar 1986

Keywords

  • Alzheimer's disease
  • Immunocytochemistry
  • Neurofibrillary degeneration
  • Pick bodies
  • Thioflavine-S

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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