Physiology of Cholngiocytes

Anatoliy I. Masyuk, Tatyana V. Masyuk, Nicholas F La Russo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cholangiocytes are epithelial cells that line the network of interconnecting intrahepatic and extrahepatic bile ducts. The main physiologic function of cholangiocytes is the modification of the bile within the ductal lumen via coordinated bidirectional vectorial transport of ions, solutes, and water. These complex processes are regulated by extracellular signaling molecules, components of bile, and physical forces via various intracellular signaling pathways. The secretory and reabsorptive functions of cholangiocytes and the mechanisms by which these functions are regulated are reviewed in this chapter.

Original languageEnglish (US)
Title of host publicationPhysiology of the Gastrointestinal Tract
Subtitle of host publicationSixth Edition
PublisherElsevier Inc.
Pages1003-1023
Number of pages21
Volume2-2
ISBN (Electronic)9780128124260
ISBN (Print)9780128099544
DOIs
StatePublished - Mar 28 2018

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Keywords

  • Absorption
  • Biliary tree
  • Cholangiocytes
  • Ductal bile
  • Intrahepatic and extrahepatic bile ducts
  • Secretion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Masyuk, A. I., Masyuk, T. V., & La Russo, N. F. (2018). Physiology of Cholngiocytes. In Physiology of the Gastrointestinal Tract: Sixth Edition (Vol. 2-2, pp. 1003-1023). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809954-4.00044-X