Physiology of Bone Loss

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The physiology of bone loss in aging women and men is largely explained by the effects of gonadal sex steroid deficiency on the skeleton. In women, estrogen deficiency is the main cause of early rapid postmenopausal bone loss, whereas hyperparathyroidism and vitamin D deficiency are thought to explain age-related bone loss later in life. Surprisingly, estrogen deficiency also plays a dominant role in the physiology of bone loss in aging men. Many other factors contribute to bone loss in aging women and men, including defective bone formation by aging osteoblasts, impairment of the growth hormone/insulin-like growth factor axis, reduced peak bone mass, age-associated sarcopenia, leptin secreted by adipocytes, serotonin secreted by the intestine, and a long list of sporadic secondary causes. Further elucidation of the relative importance of each of these factors will lead to improved preventive and therapeutic approaches for osteoporosis.

Original languageEnglish (US)
Pages (from-to)483-495
Number of pages13
JournalRadiologic Clinics of North America
Volume48
Issue number3
DOIs
StatePublished - May 2010

Fingerprint

Bone and Bones
Osteoporosis
Estrogens
Sarcopenia
Postmenopausal Osteoporosis
Vitamin D Deficiency
Hyperparathyroidism
Somatomedins
Leptin
Osteoblasts
Adipocytes
Osteogenesis
Skeleton
Growth Hormone
Intestines
Serotonin
Steroids
Therapeutics

Keywords

  • Aging
  • Bone density
  • Bone loss
  • Fractures
  • Osteopenia
  • Osteoporosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Physiology of Bone Loss. / Clarke, Bart; Khosla, Sundeep.

In: Radiologic Clinics of North America, Vol. 48, No. 3, 05.2010, p. 483-495.

Research output: Contribution to journalArticle

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