TY - JOUR
T1 - Physiology of 24,25-dihydroxyvitamin D3 in normal human subjects
AU - Kumar, R.
AU - Wiesner, R.
AU - Scott, M.
AU - Go, V. L.W.
PY - 1982
Y1 - 1982
N2 - The authors determined the metabolic clearance and production rates of 24,25-dihydroxyvitamin D3 in four normal healthy adults. They also examined the excretion of radioactivity in stool, urine, and bile after the intravenous administration of 24,25-[3H]dihydroxyvitamin D3 to human subjects. 24,25-Dihydroxyvitamin D3 is rapidly cleared from the plasma with a half-life of ~ 390 ± 25 min (mean ± SE). The metabolic clearance rate of 24,25-dihydroxyvitamin D3 was 9.2 ± 1.5 liters/day with a production rate of 26.4 ± 7.2 μg/day (mean ± SE). Within 1 day 13.0 ± 4.2% (mean ± SE) of the administered dose had appeared in the stool: by day 7, 48.8 ± 2.7% of the dose had appeared in the feces. Within 24 hr, 6.4 ± 0.8% of the administered dose appeared in the urine; 7.4 ± 1.8% of the dose had appeared in the urine within 2 days. The biliary excretion of 24,25-dihydroxyvitamin D3 was studied in two subjects. By 8 h, 15.3 ± 1.3% of the administered dose had appeared in the bile. The metabolites present in bile, feces, and urine were much more polar than 24,25-dihydroxyvitamin D3. These results demonstrate that 24,25-dihydroxyvitamin D3 is rapidly cleared from plasma and is excreted in the feces (probably via the bile) and urine of normal human subjects.
AB - The authors determined the metabolic clearance and production rates of 24,25-dihydroxyvitamin D3 in four normal healthy adults. They also examined the excretion of radioactivity in stool, urine, and bile after the intravenous administration of 24,25-[3H]dihydroxyvitamin D3 to human subjects. 24,25-Dihydroxyvitamin D3 is rapidly cleared from the plasma with a half-life of ~ 390 ± 25 min (mean ± SE). The metabolic clearance rate of 24,25-dihydroxyvitamin D3 was 9.2 ± 1.5 liters/day with a production rate of 26.4 ± 7.2 μg/day (mean ± SE). Within 1 day 13.0 ± 4.2% (mean ± SE) of the administered dose had appeared in the stool: by day 7, 48.8 ± 2.7% of the dose had appeared in the feces. Within 24 hr, 6.4 ± 0.8% of the administered dose appeared in the urine; 7.4 ± 1.8% of the dose had appeared in the urine within 2 days. The biliary excretion of 24,25-dihydroxyvitamin D3 was studied in two subjects. By 8 h, 15.3 ± 1.3% of the administered dose had appeared in the bile. The metabolites present in bile, feces, and urine were much more polar than 24,25-dihydroxyvitamin D3. These results demonstrate that 24,25-dihydroxyvitamin D3 is rapidly cleared from plasma and is excreted in the feces (probably via the bile) and urine of normal human subjects.
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U2 - 10.1152/ajpendo.1982.243.5.e370
DO - 10.1152/ajpendo.1982.243.5.e370
M3 - Article
C2 - 6753604
AN - SCOPUS:0020216358
SN - 0193-1849
VL - 6
SP - E370-E374
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 5
ER -