Physiology and function of platelets from patients with Alzheimer's disease

Gundu H.R. Rao, Janet D. Peller, David S. Knopman, James G. White

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The discovery that intact Alzheimer amyloid precursor protein is present in platelet granules, has created a great interest in the biochemistry, physiology and function of platelets of patients with Alzheimer disease (AD). In this study we monitored various biochemical and physiological parameters, such as serotonin and adenine nucleotide levels, membrane fluidity, agonist-mediated release of arachidonic acid, thromboxane formation, calcium mobilization, as well as irreversible aggregation and secretion of granule contents. Platelets of patients with AD responded poorly when stirred with weak or potent agonists on a platelet aggregometer. Although capable of agonist-mediated calcium mobilization and synthesis of thromboxanes, the aggregation response of platelets of patients with AD to thrombin and archidonate was considerably compromised. In view of the normal biochemistry and signal transduction capabilities, the compromised response of these cells to potent agonists like thrombin suggested an extrinsic defect. The present study has shown that a plasmatic factor is at least in part responsible for the functional abnormalities of AD platelets.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalIndian Journal of Physiology and Pharmacology
Volume40
Issue number1
StatePublished - Jan 1 1996

Keywords

  • alzheimer's disease
  • platelet biochemistry
  • platelet function

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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