Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis

William Stephen Brimijoin, Vicky Ping Chen, Yuan-Ping Pang, Liyi Geng, Yang Gao

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Butyrylcholinesterase (BChE) has long been regarded as an "orphan enzyme" with no specific physiological role other than to metabolize exogenous bioactive esters in the diet or in medicines. Human beings with genetic mutations that eliminate all BChE activity appear completely normal, and BChE-knockout mice have been described as "lacking a phenotype" except for faster weight gain on high-fat diets. However, our recent studies with viral gene transfer of BChE in mice reveal that BChE hydrolyzes the so-called "hunger hormone," ghrelin, at a rate which strongly affects the circulating levels of this peptide hormone. This action has important consequences for weight gain and fat metabolism. Surprisingly, it also impacts emotional behaviors such as aggression. Overexpression of BChE leads to low ghrelin levels in the blood stream and reduces aggression and social stress in mice. Under certain circumstances these combined effects contribute to increased life-span in group-housed animals. These findings may generalize to humans, as recent clinical studies by multiple investigators indicate that, among patients with severe cardiovascular disease, longevity correlates with increasing levels of plasma BChE activity.

Original languageEnglish (US)
JournalChemico-Biological Interactions
DOIs
StateAccepted/In press - Nov 16 2015

Fingerprint

Butyrylcholinesterase
Ghrelin
Nutrition
Aggression
Weight Gain
Fats
Gene transfer
Hunger
Viral Genes
Peptide Hormones
High Fat Diet
Metabolism
Knockout Mice
Medicine
Esters
Animals
Blood
Cardiovascular Diseases
Research Personnel
Hormones

Keywords

  • Aggression
  • Butyrylcholinesterase
  • Ghrelin
  • Growth hormone secretagogue receptor
  • Obesity

ASJC Scopus subject areas

  • Toxicology

Cite this

Physiological roles for butyrylcholinesterase : A BChE-ghrelin axis. / Brimijoin, William Stephen; Chen, Vicky Ping; Pang, Yuan-Ping; Geng, Liyi; Gao, Yang.

In: Chemico-Biological Interactions, 16.11.2015.

Research output: Contribution to journalArticle

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