Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis

Stephen Brimijoin, Vicky Ping Chen, Yuan Ping Pang, Liyi Geng, Yang Gao

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Butyrylcholinesterase (BChE) has long been regarded as an “orphan enzyme” with no specific physiological role other than to metabolize exogenous bioactive esters in the diet or in medicines. Human beings with genetic mutations that eliminate all BChE activity appear completely normal, and BChE-knockout mice have been described as “lacking a phenotype” except for faster weight gain on high-fat diets. However, our recent studies with viral gene transfer of BChE in mice reveal that BChE hydrolyzes the so-called “hunger hormone,” ghrelin, at a rate which strongly affects the circulating levels of this peptide hormone. This action has important consequences for weight gain and fat metabolism. Surprisingly, it also impacts emotional behaviors such as aggression. Overexpression of BChE leads to low ghrelin levels in the blood stream and reduces aggression and social stress in mice. Under certain circumstances these combined effects contribute to increased life-span in group-housed animals. These findings may generalize to humans, as recent clinical studies by multiple investigators indicate that, among patients with severe cardiovascular disease, longevity correlates with increasing levels of plasma BChE activity.

Original languageEnglish (US)
Pages (from-to)271-275
Number of pages5
JournalChemico-biological interactions
Volume259
DOIs
StatePublished - Nov 25 2016

Keywords

  • Aggression
  • Butyrylcholinesterase
  • Ghrelin
  • Growth hormone secretagogue receptor
  • Obesity

ASJC Scopus subject areas

  • Toxicology

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