Physiological considerations important for the management of vasospasm

T. M. Sundt, J. Szurszewski, F. W. Sharbrough

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The physiological mechanisms of known importance in the control of cerebral blood flow (CBF) and smooth muscle contraction and relaxation are reviewed. The pathophysiology of vasospasm following subarachnoid hemorrhage (SAH) is correlated with an alteration of these mechanisms. It is emphasized that smooth muscle relaxation is an energy dependent process and that vasodilators require a functional smooth muscle membrane that may be severely impaired in ischemia or subarachnoid hemorrhage. The temporal profiile of ischemia from spasm is correlated with the pathophysiology of altered metabolism of smooth muscle. The relevance of this complication to the timing of aneurysm surgery in 337 cases operated by one surgeon is considered along with various drug regimens suggested for its management.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalSurgical Neurology
Volume7
Issue number5
StatePublished - 1977

Fingerprint

Smooth Muscle
Muscle Relaxation
Subarachnoid Hemorrhage
Cerebrovascular Circulation
Ischemia
Spasm
Muscle Contraction
Vasodilator Agents
Aneurysm
Membranes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Sundt, T. M., Szurszewski, J., & Sharbrough, F. W. (1977). Physiological considerations important for the management of vasospasm. Surgical Neurology, 7(5), 259-267.

Physiological considerations important for the management of vasospasm. / Sundt, T. M.; Szurszewski, J.; Sharbrough, F. W.

In: Surgical Neurology, Vol. 7, No. 5, 1977, p. 259-267.

Research output: Contribution to journalArticle

Sundt, TM, Szurszewski, J & Sharbrough, FW 1977, 'Physiological considerations important for the management of vasospasm', Surgical Neurology, vol. 7, no. 5, pp. 259-267.
Sundt TM, Szurszewski J, Sharbrough FW. Physiological considerations important for the management of vasospasm. Surgical Neurology. 1977;7(5):259-267.
Sundt, T. M. ; Szurszewski, J. ; Sharbrough, F. W. / Physiological considerations important for the management of vasospasm. In: Surgical Neurology. 1977 ; Vol. 7, No. 5. pp. 259-267.
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