Physical health status measures predict all-cause mortality in patients with heart failure

Alanna Chamberlain, Sheila M. McNallan, Shannon M Dunlay, John A. Spertus, Margaret May Redfield, Debra K. Moser, Robert L. Kane, Susan A. Weston, Veronique Lee Roger

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background-Physical health status measures have been shown to predict death in heart failure (HF); however, few studies found significant associations after adjustment for confounders, and most were not representative of all HF patients. Methods and Results-HF patients from southeastern MN were prospectively enrolled between 10/2007 and 12/2010, completed a 12-item Short Form Health Survey (SF-12) and a 6-minute walk, and were followed through 2011 for death from any cause. Scores ≤25 on the SF-12 physical component indicated low self-reported physical functioning, and the first question of the SF-12 measured self-rated general health. Low functional exercise capacity was defined as ≤300 m walked during a 6-minute walk. Over a mean follow-up of 2.3 years, 86 deaths occurred among the 352 participants. A 1.6-fold (95% confidence interval, 1.0-2.7) and 1.8-fold (95% confidence interval, 1.1-2.9) increased risk of death was observed among patients with low self-reported physical functioning and low functional exercise capacity, respectively. Poor self-rated general health corresponded to a 2.7-fold (95% confidence interval, 1.5-4.9) increased risk of death compared with good to excellent general health. All measures equally discriminated between who would die and who would survive (C-statistics: 0.729, 0.750, and 0.740 for self-reported physical functioning, self-rated general health, and functional exercise capacity, respectively). Conclusions-Three physical health status measures, captured by the SF-12 and a 6-minute walk, equally predict death among community HF patients. Therefore, the first question of the SF-12, which is the least burdensome to administer, may be sufficient to identify HF patients at greatest risk of death.

Original languageEnglish (US)
Pages (from-to)669-675
Number of pages7
JournalCirculation: Heart Failure
Volume6
Issue number4
DOIs
StatePublished - Jul 2013

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Health Status
Heart Failure
Mortality
Health
Confidence Intervals
Exercise
Health Surveys
Cause of Death

Keywords

  • Health status
  • Heart failure
  • Mortality
  • Physical functioning
  • Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Physical health status measures predict all-cause mortality in patients with heart failure. / Chamberlain, Alanna; McNallan, Sheila M.; Dunlay, Shannon M; Spertus, John A.; Redfield, Margaret May; Moser, Debra K.; Kane, Robert L.; Weston, Susan A.; Roger, Veronique Lee.

In: Circulation: Heart Failure, Vol. 6, No. 4, 07.2013, p. 669-675.

Research output: Contribution to journalArticle

Chamberlain, Alanna ; McNallan, Sheila M. ; Dunlay, Shannon M ; Spertus, John A. ; Redfield, Margaret May ; Moser, Debra K. ; Kane, Robert L. ; Weston, Susan A. ; Roger, Veronique Lee. / Physical health status measures predict all-cause mortality in patients with heart failure. In: Circulation: Heart Failure. 2013 ; Vol. 6, No. 4. pp. 669-675.
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AU - McNallan, Sheila M.

AU - Dunlay, Shannon M

AU - Spertus, John A.

AU - Redfield, Margaret May

AU - Moser, Debra K.

AU - Kane, Robert L.

AU - Weston, Susan A.

AU - Roger, Veronique Lee

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