Abstract
We have studied the biological effects of ablation-induced stress waves in vitro. Mouse breast sarcoma cells (EMT-6) were exposed to stress waves that differed only in rise time. Two assays were used to determine cell injury: incorporation of tritiated thymidine (viability assay), and transmission electron microscopy (morphology assay). We present evidence that the rise time of stress waves can significantly modify cell viability and that cell injury correlates better with the stress gradient than peak stress.
Original language | English (US) |
---|---|
Pages (from-to) | 961-967 |
Number of pages | 7 |
Journal | Ultrasound in Medicine and Biology |
Volume | 21 |
Issue number | 7 |
DOIs | |
State | Published - 1995 |
Keywords
- Ablation
- Cell viability
- Membrane permeability
- Photoacoustics
- Shock waves
- Stress gradient
ASJC Scopus subject areas
- Biophysics
- Radiological and Ultrasound Technology
- Acoustics and Ultrasonics