Physical factors involved in stress-wave-induced cell injury: The effect of stress gradient

Apostolos G. Doukas, Daniel J. McAuliffe, Shun Lee, Vasan Venugopalan, Thomas J. Flotte

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

We have studied the biological effects of ablation-induced stress waves in vitro. Mouse breast sarcoma cells (EMT-6) were exposed to stress waves that differed only in rise time. Two assays were used to determine cell injury: incorporation of tritiated thymidine (viability assay), and transmission electron microscopy (morphology assay). We present evidence that the rise time of stress waves can significantly modify cell viability and that cell injury correlates better with the stress gradient than peak stress.

Original languageEnglish (US)
Pages (from-to)961-967
Number of pages7
JournalUltrasound in Medicine and Biology
Volume21
Issue number7
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Ablation
  • Cell viability
  • Membrane permeability
  • Photoacoustics
  • Shock waves
  • Stress gradient

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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