Physical activity, physical function, and the risk of breast cancer in a prospective study among elderly women

James R Cerhan, B. C H Chiu, Robert B. Wallace, Jon H. Lemke, Charles F. Lynch, James C. Torner, Linda M. Rubenstein

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background. Accumulating evidence suggests that physical activity may protect against the development of breast cancer, but less is known about the role of modest physical activity during the postmenopausal years and in the context of physical function. Methods. We evaluated this association in the Iowa 65+ Rural Health Study, a population-based, prospective cohort study of elderly adults. The cohort was linked to a population-based cancer registry for the years 1973-93, and the at-risk cohort consisted of 1,806 women ages 65 to 102 years with an in-person baseline interview in 1982 and with no documented cancer between 1973 and the baseline interview. Through 1993 (16,857 person-years of follow-up) there were 46 incident cases of breast cancer. Results. Greater level of physical activity in women with no physical disabilities was inversely associated with breast cancer risk (p for trend = .01). Compared to inactive women with no physical disability, women reporting moderate (age-adjusted relative risk [RR] = 0.5, 95% confidence interval [CI] 0.3-1.1) or high (age-adjusted RR = 0.2, 95% CI .05-0.9) activity leVelS were at decreased risk of breast cancer. Women with any disability were also at decreased risk of breast cancer compared to inactive women with no disability (age-adjusted RR = 0.4; 95% CI 0.2-0.9). Adjustment for education, body mass index, age at menarche, age at menopause, previous use of hormone replacement therapy, pregnancy history, systolic blood pressure, smoking, and alcohol use did not alter these associations. In addition, these associations were similar after exclusion of cases occurring during the first two years of follow-up, after adjusting for the number of doctor visits, and after stratifying by stage at diagnosis. Conclusions. These data suggest that postmenopausal activity level, after accounting for physical disability, is inversely associated with breast cancer risk.

Original languageEnglish (US)
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume53
Issue number4
StatePublished - 1998
Externally publishedYes

Fingerprint

Prospective Studies
Exercise
Breast Neoplasms
Confidence Intervals
Interviews
Blood Pressure
Rural Health
Reproductive History
Menarche
Age Factors
Hormone Replacement Therapy
Menopause
Population
Registries
Neoplasms
Body Mass Index
Cohort Studies
Smoking
Alcohols
Education

ASJC Scopus subject areas

  • Aging

Cite this

Physical activity, physical function, and the risk of breast cancer in a prospective study among elderly women. / Cerhan, James R; Chiu, B. C H; Wallace, Robert B.; Lemke, Jon H.; Lynch, Charles F.; Torner, James C.; Rubenstein, Linda M.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 53, No. 4, 1998.

Research output: Contribution to journalArticle

Cerhan, James R ; Chiu, B. C H ; Wallace, Robert B. ; Lemke, Jon H. ; Lynch, Charles F. ; Torner, James C. ; Rubenstein, Linda M. / Physical activity, physical function, and the risk of breast cancer in a prospective study among elderly women. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 1998 ; Vol. 53, No. 4.
@article{98debb8fe6f74dde9da0966a83ae937b,
title = "Physical activity, physical function, and the risk of breast cancer in a prospective study among elderly women",
abstract = "Background. Accumulating evidence suggests that physical activity may protect against the development of breast cancer, but less is known about the role of modest physical activity during the postmenopausal years and in the context of physical function. Methods. We evaluated this association in the Iowa 65+ Rural Health Study, a population-based, prospective cohort study of elderly adults. The cohort was linked to a population-based cancer registry for the years 1973-93, and the at-risk cohort consisted of 1,806 women ages 65 to 102 years with an in-person baseline interview in 1982 and with no documented cancer between 1973 and the baseline interview. Through 1993 (16,857 person-years of follow-up) there were 46 incident cases of breast cancer. Results. Greater level of physical activity in women with no physical disabilities was inversely associated with breast cancer risk (p for trend = .01). Compared to inactive women with no physical disability, women reporting moderate (age-adjusted relative risk [RR] = 0.5, 95{\%} confidence interval [CI] 0.3-1.1) or high (age-adjusted RR = 0.2, 95{\%} CI .05-0.9) activity leVelS were at decreased risk of breast cancer. Women with any disability were also at decreased risk of breast cancer compared to inactive women with no disability (age-adjusted RR = 0.4; 95{\%} CI 0.2-0.9). Adjustment for education, body mass index, age at menarche, age at menopause, previous use of hormone replacement therapy, pregnancy history, systolic blood pressure, smoking, and alcohol use did not alter these associations. In addition, these associations were similar after exclusion of cases occurring during the first two years of follow-up, after adjusting for the number of doctor visits, and after stratifying by stage at diagnosis. Conclusions. These data suggest that postmenopausal activity level, after accounting for physical disability, is inversely associated with breast cancer risk.",
author = "Cerhan, {James R} and Chiu, {B. C H} and Wallace, {Robert B.} and Lemke, {Jon H.} and Lynch, {Charles F.} and Torner, {James C.} and Rubenstein, {Linda M.}",
year = "1998",
language = "English (US)",
volume = "53",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Physical activity, physical function, and the risk of breast cancer in a prospective study among elderly women

AU - Cerhan, James R

AU - Chiu, B. C H

AU - Wallace, Robert B.

AU - Lemke, Jon H.

AU - Lynch, Charles F.

AU - Torner, James C.

AU - Rubenstein, Linda M.

PY - 1998

Y1 - 1998

N2 - Background. Accumulating evidence suggests that physical activity may protect against the development of breast cancer, but less is known about the role of modest physical activity during the postmenopausal years and in the context of physical function. Methods. We evaluated this association in the Iowa 65+ Rural Health Study, a population-based, prospective cohort study of elderly adults. The cohort was linked to a population-based cancer registry for the years 1973-93, and the at-risk cohort consisted of 1,806 women ages 65 to 102 years with an in-person baseline interview in 1982 and with no documented cancer between 1973 and the baseline interview. Through 1993 (16,857 person-years of follow-up) there were 46 incident cases of breast cancer. Results. Greater level of physical activity in women with no physical disabilities was inversely associated with breast cancer risk (p for trend = .01). Compared to inactive women with no physical disability, women reporting moderate (age-adjusted relative risk [RR] = 0.5, 95% confidence interval [CI] 0.3-1.1) or high (age-adjusted RR = 0.2, 95% CI .05-0.9) activity leVelS were at decreased risk of breast cancer. Women with any disability were also at decreased risk of breast cancer compared to inactive women with no disability (age-adjusted RR = 0.4; 95% CI 0.2-0.9). Adjustment for education, body mass index, age at menarche, age at menopause, previous use of hormone replacement therapy, pregnancy history, systolic blood pressure, smoking, and alcohol use did not alter these associations. In addition, these associations were similar after exclusion of cases occurring during the first two years of follow-up, after adjusting for the number of doctor visits, and after stratifying by stage at diagnosis. Conclusions. These data suggest that postmenopausal activity level, after accounting for physical disability, is inversely associated with breast cancer risk.

AB - Background. Accumulating evidence suggests that physical activity may protect against the development of breast cancer, but less is known about the role of modest physical activity during the postmenopausal years and in the context of physical function. Methods. We evaluated this association in the Iowa 65+ Rural Health Study, a population-based, prospective cohort study of elderly adults. The cohort was linked to a population-based cancer registry for the years 1973-93, and the at-risk cohort consisted of 1,806 women ages 65 to 102 years with an in-person baseline interview in 1982 and with no documented cancer between 1973 and the baseline interview. Through 1993 (16,857 person-years of follow-up) there were 46 incident cases of breast cancer. Results. Greater level of physical activity in women with no physical disabilities was inversely associated with breast cancer risk (p for trend = .01). Compared to inactive women with no physical disability, women reporting moderate (age-adjusted relative risk [RR] = 0.5, 95% confidence interval [CI] 0.3-1.1) or high (age-adjusted RR = 0.2, 95% CI .05-0.9) activity leVelS were at decreased risk of breast cancer. Women with any disability were also at decreased risk of breast cancer compared to inactive women with no disability (age-adjusted RR = 0.4; 95% CI 0.2-0.9). Adjustment for education, body mass index, age at menarche, age at menopause, previous use of hormone replacement therapy, pregnancy history, systolic blood pressure, smoking, and alcohol use did not alter these associations. In addition, these associations were similar after exclusion of cases occurring during the first two years of follow-up, after adjusting for the number of doctor visits, and after stratifying by stage at diagnosis. Conclusions. These data suggest that postmenopausal activity level, after accounting for physical disability, is inversely associated with breast cancer risk.

UR - http://www.scopus.com/inward/record.url?scp=0031927431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031927431&partnerID=8YFLogxK

M3 - Article

C2 - 18314563

AN - SCOPUS:0031927431

VL - 53

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 4

ER -