Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers

Lisa H. Colbert, Terryl J. Hartman, Nea Malila, Paul J. Limburg, Pirjo Pietinen, Jarmo Virtamo, Philip R. Taylor, Demetrius Albanes

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95 Scopus citations

Abstract

We examined the association between occupational and leisure physical activity and colorectal cancer in a cohort of male smokers. Among the 29,133 men aged 50-69 years in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study, 152 colon and 104 rectal cancers were documented during up to 12 years of follow-up. For colon cancer, compared with sedentary workers, men in light occupational activity had a relative risk (RR) of 0.60 [95% confidence interval (CI), 0.34-1.04], whereas those in moderate/heavy activity had an RR of 0.45 (CI, 0.26-0.78; P for trend, 0.003). Subsite analysis revealed a significant association for moderate/heavy occupational activity in the distal colon (RR, 0.21; CI, 0.09-0.51) but not in the proximal colon (RR, 0.87; CI, 0.40-1.92). There was no significant association between leisure activity and colon cancer (active versus sedentary; RR, 0.82; CI, 0.59-1.13); however, the strongest inverse association was found among those most active in both work and leisure (RR, 0.33; CI, 0.16-0.71). For rectal cancer, there were risk reductions for those in light (RR, 0.71; CI, 0.36-1.37) and moderate/heavy occupational activity (RR, 0.50; CI, 0.26-0.97; P for trend, 0.04), and no association for leisure activity. These data provide evidence for a protective role of physical activity in colon and rectal cancer.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number3
StatePublished - Mar 2001

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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    Colbert, L. H., Hartman, T. J., Malila, N., Limburg, P. J., Pietinen, P., Virtamo, J., Taylor, P. R., & Albanes, D. (2001). Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers. Cancer Epidemiology Biomarkers and Prevention, 10(3), 265-268.